MRPL20 and ITSN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MRPL20	ITSN1
Gene Name		mitochondrial ribosomal protein L20	intersectin 1 (SH3 domain protein)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Ribosome	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse
	Molecular Function	Structural Constituent Of Ribosome Protein Binding RRNA Binding Poly(A) RNA Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding
	Biological Process	Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ACP1 APP CALM2 CAPZB DUSP23 EPS8 ITSN1 OXA1L TP53BP2 USP13	82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2
Entrez ID		55052	6453
HPRD ID		14746	03898
Ensembl ID		ENSG00000242485	ENSG00000205726
Uniprot IDs		B7Z746 Q9BYC9	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs			1KI1 2KGR 2KHN 3FIA 3QBV 4IIM
Enriched GO Terms of Interacting Partners?		Barbed-end Actin Filament Capping Actin Filament Capping Negative Regulation Of Actin Filament Depolymerization Regulation Of Signal Transduction Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Platelet Degranulation Regulation Of Oxidoreductase Activity Negative Regulation Of Protein Polymerization Blood Coagulation Regulation Of Signaling Negative Regulation Of Protein Complex Disassembly Hemostasis Response To Radiation Regulation Of Protein Depolymerization Synaptic Growth At Neuromuscular Junction Mitochondrial Proton-transporting ATP Synthase Complex Assembly Adult Locomotory Behavior Regulation Of Protein Complex Disassembly Negative Regulation Of Protein Complex Assembly Actin Polymerization-dependent Cell Motility Collateral Sprouting In Absence Of Injury Nervous System Development Regulation Of Body Fluid Levels Proton-transporting ATP Synthase Complex Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Wound Healing Negative Regulation Of Cytoskeleton Organization Collateral Sprouting Axon Midline Choice Point Recognition Epidermal Growth Factor Receptor Signaling Pathway Adult Behavior ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Dephosphorylation Regulation Of Actin Filament Polymerization Movement Of Cell Or Subcellular Component Negative Regulation Of Filopodium Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of High Voltage-gated Calcium Channel Activity Response To Wounding Exit From Mitosis Axon Choice Point Recognition Platelet Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of ATPase Activity	Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis
Tagcloud ?		capza1 cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Difference) ?		capza1 cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Intersection) ?