PHIP and IRS1

Number of citations of the paper that reports this interaction (PubMedID 11018022)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PHIP	IRS1
Description		PHIP subunit of CUL4-Ring ligase complex	insulin receptor substrate 1
Image
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Intracellular Membrane-bounded Organelle
	Molecular Function	Insulin Receptor Binding Protein Binding Histone Reader Activity	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Signaling Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity SH2 Domain Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Regulation Of Protein Phosphorylation Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Cell Shape Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Glucose Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Fatty Acid
Pathways		RHOBTB2 GTPase cycle	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Signaling by ALK Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Activated NTRK3 signals through PI3K Signaling by ALK fusions and activated point mutants Growth hormone receptor signaling Signaling by LTK
Drugs			[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Diastolic blood pressure ( 27618448 27841878) Intelligence (MTAG) ( 29326435) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Mean arterial pressure ( 27618448) Sjögren's syndrome ( 24097067) Systolic blood pressure ( 27841878 30578418)	Adiponectin levels ( 22479202 31178129) Adiposity ( 21706003) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 28724990 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Birth weight ( 31043758) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage ( 28270201 26833246) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) Glucose homeostasis traits ( 25524916) HDL cholesterol ( 25961943 20686565 24097068) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) Lean body mass ( 28724990) Leg fat mass (lean adjusted) ( 32719433) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Metabolite levels ( 23823483) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Myocardial infarction ( 33532862) Problematic alcohol use ( 32451486) Sexual dimorphism in anthropometric traits ( 23754948) Spleen volume ( 34128465) Triglyceride levels ( 28334899 32203549) Triglycerides ( 25961943 24097068 20686565) Type 2 diabetes ( 20581827 31118516 30297969 29358691 24509480 22885922 19734900) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference ( 25673412) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		3 interacting genes: IRS1 STMN4 TUBB3	81 interacting genes: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK3 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 NUMB PASK PDPK1 PELI1 PELI2 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRD PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SHC1 SIK2 SOCS1 SOCS3 TRAF4 TRIM72 TUB TYK2 UBC UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID		55023	3667
HPRD ID		10152	00943
Ensembl ID		ENSG00000146247	ENSG00000169047
Uniprot IDs		A0A8V8TPV5 Q8WWQ0	P35568
PDB IDs		3MB3 5ENB 5ENC 5ENE 5ENF 5ENH 5ENI 5ENJ 5RJI 5RJJ 5RJK 5RJL 5RJM 5RJN 5RJO 5RJP 5RJQ 5RJR 5RJS 5RJT 5RJU 5RJV 5RJW 5RJX 5RJY 5RJZ 5RK0 5RK1 5RK2 5RK3 5RK4 5RK5 5RK6 5RK7 5RK8 5RK9 5RKA 5RKB 5RKC 5RKD 5RKE 5RKF 5RKG 5RKH 5RKI 5RKJ 5RKK 5RKL 5RKM 5RKN 5RKO 5RKP 5RKQ 5RKR 5RKS 5RKT 5RKU 5RKV 5RKW 5RKX 5RKY 5S8C 5S8D 5S8E 5S8F 5S8G 5S8H 5S8I 5S8J 5S8K 5S8L 5S8M 5S8N 5S8O 5S8P 5S8Q 5S8R 5S8S 5S8T 5S8U 5S8V 5S8W 5S8X 5S8Y 5S8Z 5S90 5S91 5S92 5S93 5S94 5S95 5S96 5S97 5S98 5S99 5S9A 5S9B 5S9C 5S9D 5S9E 5S9G 5S9J 7AV8 7AV9 7BBO 7BBP 7FUS 7FUT 7FUU 7FUV 7FUW 7FUX 7FUY 7FUZ 7FV0 7FV1 7FV2 7FV3 7FV4 7FV5 7FV6 7FV7 7FV8 7FV9 7FVA 7FVB 7FVC 7FVD 7FVE 7FVF 7FVG 7FVH 7FVI 7FVJ 7FVK 7FVL 7FVM 7FVN 7FVO 7FVP 7FVQ 7FVR 8BW2 8BW3 8BW4 9GH3	1IRS 1K3A 1QQG 2Z8C 5U1M 6BNT 7PPL 7PPM
Enriched GO Terms of Interacting Partners?		Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Insulin Receptor Complex Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fatty Acid Beta-oxidation Insulin-like Growth Factor Receptor Binding Positive Regulation Of Fatty Acid Oxidation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Netrin-activated Signaling Pathway Axon Netrin Receptor Binding Ganglion Development Dorsal Root Ganglion Development Microtubule Cytoskeleton Organization Neuron Projection Development Growth Cone Microtubule Depolymerization Negative Regulation Of Insulin Secretion Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Cellular Response To Insulin Stimulus SH2 Domain Binding Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Fatty Acid Positive Regulation Of Lipid Catabolic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Peptide Secretion Positive Regulation Of D-glucose Import Protein Kinase C Binding Regulation Of Fatty Acid Oxidation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Transmembrane Transport Insulin Receptor Binding Regulation Of Glycogen Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Plasma Membrane Bounded Cell Projection Organization Peptide Binding Microtubule-based Process Microtubule Polymerization Or Depolymerization Protein Depolymerization Cytoskeleton Organization Response To Fatty Acid Regulation Of Lipid Catabolic Process Regulation Of D-glucose Import Tubulin Binding Cell Projection Organization Negative Regulation Of Hormone Secretion	Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Signaling Pathway Protein Phosphorylation Protein Kinase Activity Phosphorylation Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Regulation Of Immune Response Regulation Of Cellular Component Organization Phosphate-containing Compound Metabolic Process Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Response To Stress Negative Regulation Of Signal Transduction ATP Binding Regulation Of Immune System Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Multicellular Organismal Process Phosphotyrosine Residue Binding Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Transferase Activity Regulation Of Developmental Process Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Stress Intracellular Signaling Cassette Positive Regulation Of Immune System Process Positive Regulation Of Metabolic Process Cellular Response To Oxygen-containing Compound
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