PHIP and TUBB3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PHIP	TUBB3
Gene Name		pleckstrin homology domain interacting protein	tubulin, beta 3 class III
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Nucleus Cytoplasm Microtubule Axon Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Insulin Receptor Binding Protein Binding Lysine-acetylated Histone Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding
	Biological Process	Regulation Of Protein Phosphorylation Protein Import Into Nucleus Cytoskeleton Organization Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Morphogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Folding Microtubule-based Process Mitotic Nuclear Division Axon Guidance Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Transmembrane Transport
Pathways			Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Epothilone D Epothilone B Ixabepilone
Diseases
GWAS
Protein-Protein Interactions		3 interactors: IRS1 STMN4 TUBB3	27 interactors: ANXA7 ARHGEF7 CAMSAP3 CDKN1A DDX39B EEF1G GABARAP GZMK HEXDC INSM1 KHDRBS1 LAPTM4A LIG1 MRPL28 MTCL1 PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		55023	10381
HPRD ID		10152	04044
Ensembl ID		ENSG00000146247	ENSG00000258947
Uniprot IDs		A7J992 Q8WWQ0	A8K854 Q13509 Q53G92
PDB IDs		3MB3
Enriched GO Terms of Interacting Partners?		Microtubule Depolymerization Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Phosphatidylinositol 3-kinase Signaling Microtubule-based Process Positive Regulation Of Insulin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Positive Regulation Of Lipid Catabolic Process Cellular Response To Growth Hormone Stimulus Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Metabolic Process Neuron Development Regulation Of Glycogen Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Protein Kinase B Signaling Response To Growth Hormone Microtubule Polymerization Or Depolymerization Negative Regulation Of Peptide Secretion Positive Regulation Of Mesenchymal Cell Proliferation System Development Positive Regulation Of Glucose Import Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Glucose Transport Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Differentiation JAK-STAT Cascade Cell Projection Organization 'de Novo' Posttranslational Protein Folding Regulation Of Lipid Catabolic Process Regulation Of Lipid Kinase Activity 'de Novo' Protein Folding Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Multicellular Organismal Development Regulation Of Glucose Import Anatomical Structure Development Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Stem Cell Proliferation Regulation Of Generation Of Precursor Metabolites And Energy	Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Mitotic Cell Cycle Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Division Cell Cycle Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Response To Toxic Substance Negative Regulation Of Chromosome Segregation Cell Division Cytoskeleton Organization Microtubule Bundle Formation Positive Regulation Of Microtubule Motor Activity Fetal Process Involved In Parturition Columnar/cuboidal Epithelial Cell Development Regulation Of DNA Biosynthetic Process Microtubule-based Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Epithelial Cell Development Regulation Of Cell Morphogenesis Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Spliceosomal Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		achievable affordable benzo butanone carcinogenesis carcinogens coexposure cooked endpoints ergosterol holistically intervene legumes meats methylnitrosamino mimosine mushrooms nbp nnk noncytotoxic phenylimidazo physiologically polluted pyrene pyridine pyridyl reinforced sporadically talk	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tyms vegfr2
Tagcloud (Difference) ?		achievable affordable benzo butanone carcinogenesis carcinogens coexposure cooked endpoints ergosterol holistically intervene legumes meats methylnitrosamino mimosine mushrooms nbp nnk noncytotoxic phenylimidazo physiologically polluted pyrene pyridine pyridyl reinforced sporadically talk	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tyms vegfr2
Tagcloud (Intersection) ?