PPP1CB and ZFYVE9

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPP1CB	ZFYVE9
Gene Name		protein phosphatase 1, catalytic subunit, beta isozyme	zinc finger, FYVE domain containing 9
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Nucleolus Focal Adhesion Glycogen Granule Extracellular Vesicular Exosome MLL5-L Complex PTW/PP1 Phosphatase Complex	Early Endosome Early Endosome Membrane
	Molecular Function	Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity	Protein Binding 1-phosphatidylinositol Binding Serine-type Peptidase Activity Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Regulation Of Cell Adhesion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division	Proteolysis Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Metabolism of lipids and lipoproteins Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer G2/M Transition TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Regulation of PLK1 Activity at G2/M Transition Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Mitotic G2-G2/M phases SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: AURKA BRCA1 CSRNP2 NONO PPP1R12B PPP1R12C PPP1R16A PPP1R2P3 PPP1R3C PPP1R9B PRKAR2A PTK2 RB1 SH2D4A TLX1 TP53BP2 WBP11 ZFYVE9	38 interactors: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBB2IP ETS2 FAM46A FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPG20 ST7 SUMF2 SUPT5H SVEP1 TGFBR1 TGFBR2 UBC UBXN11 ZMYND8
Entrez ID		5500	9372
HPRD ID		11792	04782
Ensembl ID		ENSG00000213639	ENSG00000157077
Uniprot IDs		P62140	O95405
PDB IDs			1DEV 1MK2 4BKW
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of Phosphatase Activity Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Dephosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Regulation Of Organelle Organization Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Protein Catabolic Process Apoptotic Process Androgen Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Programmed Cell Death Positive Regulation Of Cell Cycle Process Cell Cycle Process Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cell Division Neuron Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Spindle Checkpoint Regulation Of Lipid Kinase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphatase Activity Glycogen Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Common-partner SMAD Protein Phosphorylation Cell Cycle Trachea Formation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Embryonic Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Embryonic Cranial Skeleton Morphogenesis Cellular Response To Organic Substance Response To Organic Substance Photoperiodism Entrainment Of Circadian Clock Embryonic Skeletal System Development Lens Development In Camera-type Eye Cell Cycle Process Regulation Of Growth Signal Transduction Trachea Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Embryonic Foregut Morphogenesis Regulation Of Gene Expression Foregut Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Lung Development Negative Regulation Of Growth Negative Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Respiratory Tube Development Glycogen Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Skeletal System Morphogenesis Tube Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Death
Tagcloud ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes
Tagcloud (Difference) ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes
Tagcloud (Intersection) ?