PPP1CB and UBAC1

Number of citations of the paper that reports this interaction (PubMedID 31323436)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		PPP1CB	UBAC1
Description		protein phosphatase 1 catalytic subunit beta	UBA domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Focal Adhesion Extracellular Exosome PTW/PP1 Phosphatase Complex	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity	Protein Binding Polyubiquitin Modification-dependent Protein Binding Proteasome Binding
	Biological Process	MAPK Cascade Glycogen Metabolic Process Protein Dephosphorylation Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Rhythmic Process Cell Division	Protein Ubiquitination Protein Maturation
Pathways		Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 28869591 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		46 interacting genes: ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NONO PHACTR3 PPP1R11 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP2R5C PRKAR2A PTK2 RB1 RORC SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9	37 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A FAS HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MECOM MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBC UBQLN2 WWP2 ZDHHC17 ZG16B
Entrez ID		5500	10422
HPRD ID		11792	12170
Ensembl ID		ENSG00000213639	ENSG00000130560
Uniprot IDs		P62140 V9HW04	A0A140VK64 Q9BSL1
PDB IDs			2DAI
Enriched GO Terms of Interacting Partners?		Myosin Phosphatase Regulator Activity Protein Phosphatase Inhibitor Activity Phosphatase Regulator Activity Protein Phosphatase 1 Binding Glycogen Binding Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Phosphatase Binding Enzyme Inhibitor Activity Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Glycogen Biosynthetic Process Stress Fiber Regulation Of Centromere Complex Assembly Regulation Of Glycogen Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Kinase Binding Centrosome Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromatin Cell Projection Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle A Band Segment Specification Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Process	Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Collateral Sprouting In Absence Of Injury Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Positive Regulation Of Aggrephagy Transferase Activity Post-translational Protein Modification Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Catabolic Process Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Protein Targeting To Vacuole Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Identical Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Signal Transduction Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Segment Specification Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Regulation Of Developmental Growth Catabolic Process Receptor Catabolic Process
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