PPP1CB and WBP11

Number of citations of the paper that reports this interaction (PMID 14640981)
9

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PPP1CB	WBP11
Gene Name		protein phosphatase 1, catalytic subunit, beta isozyme	WW domain binding protein 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Nucleolus Focal Adhesion Glycogen Granule Extracellular Vesicular Exosome MLL5-L Complex PTW/PP1 Phosphatase Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity	Single-stranded DNA Binding Protein Binding Protein Phosphatase Type 1 Regulator Activity Poly(A) RNA Binding WW Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Regulation Of Cell Adhesion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division	RRNA Processing MRNA Processing RNA Splicing Regulation Of Catalytic Activity
Pathways		Loss of Function of TGFBR2 in Cancer Metabolism of lipids and lipoproteins Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer G2/M Transition TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Regulation of PLK1 Activity at G2/M Transition Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Mitotic G2-G2/M phases SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: AURKA BRCA1 CSRNP2 NONO PPP1R12B PPP1R12C PPP1R16A PPP1R2P3 PPP1R3C PPP1R9B PRKAR2A PTK2 RB1 SH2D4A TLX1 TP53BP2 WBP11 ZFYVE9	28 interactors: APBB1 ARF1 C5orf22 CD2BP2 CTNNBL1 DDX17 DDX5 FYN GIGYF2 GRB2 ITSN1 MCRS1 NCK2 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRPF40A RBM5 RTN4IP1 RUNX1T1 SRC TESC TRAF4 TRIP10 VIM WBP4
Entrez ID		5500	51729
HPRD ID		11792	18293
Ensembl ID		ENSG00000213639	ENSG00000084463
Uniprot IDs		P62140	F5H721 Q9Y2W2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of Phosphatase Activity Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Dephosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Regulation Of Organelle Organization Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Protein Catabolic Process Apoptotic Process Androgen Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Programmed Cell Death Positive Regulation Of Cell Cycle Process Cell Cycle Process Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cell Division Neuron Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Spindle Checkpoint Regulation Of Lipid Kinase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphatase Activity Glycogen Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Enzyme Linked Receptor Protein Signaling Pathway RNA Splicing Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus RNA Processing MRNA Splicing, Via Spliceosome Response To Growth Factor RNA Splicing, Via Transesterification Reactions MRNA Processing Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Cell Death Death Entrainment Of Circadian Clock By Photoperiod MRNA Metabolic Process T Cell Costimulation Triglyceride Catabolic Process Regulation Of Gene Expression Regulation Of Intracellular Estrogen Receptor Signaling Pathway Photoperiodism Entrainment Of Circadian Clock Regulation Of Signal Transduction Regulation Of Cellular Process Acylglycerol Catabolic Process Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Axon Guidance Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway Neurotrophin Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of RNA Splicing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Positive Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway System Development Response To Radiation Developmental Process Anatomical Structure Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Neuron Differentiation
Tagcloud ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?