VDR and PRCP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		VDR	PRCP
Gene Name		vitamin D (1,25- dihydroxyvitamin D3) receptor	prolylcarboxypeptidase (angiotensinase C)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex	Lysosome Plasma Membrane Basal Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Calcitriol Receptor Activity Lithocholic Acid Receptor Activity Sequence-specific DNA Binding Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding	Serine-type Carboxypeptidase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Skeletal System Development Transcription Initiation From RNA Polymerase II Promoter Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Lactation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Decidualization Intestinal Absorption Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Calcidiol 1-monooxygenase Activity Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway	Regulation Of Thyroid Hormone Mediated Signaling Pathway Plasma Kallikrein-kinin Cascade Negative Regulation Of Systemic Arterial Blood Pressure Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Glucose Homeostasis Regulation Of Blood Vessel Endothelial Cell Migration Angiogenesis Involved In Wound Healing Energy Homeostasis Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Calcitriol Calcidiol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol 1alpha,25-Dihydroxyl-20-Epi-22-Oxa-24,26,27-Trihomovitamin D3 Seocalcitol Inecalcitol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		71 interactors: ACTN4 ACVR1 BAG1 CASC4 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 EIF3I FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MMRN2 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TCF3 TDG TRIM24 ZBTB16	2 interactors: AGT VDR
Entrez ID		7421	5547
HPRD ID		03463	08352
Ensembl ID		ENSG00000111424	ENSG00000137509
Uniprot IDs		F1D8P8 P11473	B7Z7Q6 P42785
PDB IDs		1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 4G2I	3N2Z
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Cell Communication Anatomical Structure Development Signal Transduction Cellular Response To Stimulus Response To Hormone Cellular Metabolic Process Signaling Multicellular Organismal Development Response To Organic Substance	Positive Regulation Of Oxidoreductase Activity Regulation Of Tissue Remodeling Regulation Of Oxidoreductase Activity Regulation Of Steroid Metabolic Process Regulation Of Lipid Biosynthetic Process Regulation Of Organ Morphogenesis Branching Morphogenesis Of An Epithelial Tube Uterine Smooth Muscle Contraction Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Female Pregnancy Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Lipid Metabolic Process Vitamin D Receptor Signaling Pathway Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Catenin Import Into Nucleus Positive Regulation Of Vitamin D 24-hydroxylase Activity Smooth Muscle Cell Proliferation Positive Regulation Of NAD(P)H Oxidase Activity Bile Acid Signaling Pathway Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Angiotensin-mediated Drinking Behavior Regulation Of Renal Output By Angiotensin Epithelial Tube Morphogenesis Cellular Metal Ion Homeostasis Fibroblast Proliferation Astrocyte Activation Renin-angiotensin Regulation Of Aldosterone Production Tube Morphogenesis Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Blood Vessel Size By Renin-angiotensin Metal Ion Homeostasis Reproductive Structure Development Establishment Of Blood-nerve Barrier Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Activation Of JAK2 Kinase Activity Reproductive System Development Morphogenesis Of An Epithelium Cellular Chemical Homeostasis Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Mammary Gland Branching Involved In Pregnancy Regulation Of Calcidiol 1-monooxygenase Activity
Tagcloud ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10	angiotensins approaches brain broadly carboxypeptidase deletion determine distribution endogenous gal hybridization hypothalamic hypothalamus inactivate melanocortin modulating mouse msh prekallikrein prolyl protease radioactive serine situ substrates throughout undertaken variety widely
Tagcloud (Difference) ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10	angiotensins approaches brain broadly carboxypeptidase deletion determine distribution endogenous gal hybridization hypothalamic hypothalamus inactivate melanocortin modulating mouse msh prekallikrein prolyl protease radioactive serine situ substrates throughout undertaken variety widely
Tagcloud (Intersection) ?