VDR and RPS6KC1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VDR	RPS6KC1
Name		vitamin D receptor	ribosomal protein S6 kinase C1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex	Cytoplasm Lysosome Endosome Early Endosome Membrane Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Vitamin D Binding Protein Binding Zinc Ion Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Phosphatidylinositol Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Skeletal System Development Regulation Of DNA-templated Transcription Calcium Ion Transport Intracellular Calcium Ion Homeostasis Lactation Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Phosphate Ion Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway MRNA Transcription By RNA Polymerase II Cell-cell Junction Maintenance Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Retinoic Acid Receptor Signaling Pathway Intestinal Absorption Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Negative Regulation Of Phosphate Transmembrane Transport	Signal Transduction
Pathways		Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	None
Drugs		Calcitriol Calcifediol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol Lexacalcitol Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Elocalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin Curcumin sulfate	None
Diseases		Tuberculosis Localized autosomal recessive hypotrichosis	None
GWAS		Asthma (adult onset) ( 31036433 ) Basal cell carcinoma ( 33549134 ) Eosinophil percentage of white cells ( 32888494 ) Gout ( 22179738 ) Gut microbiota (beta diversity) ( 27723756 ) Inflammatory bowel disease ( 23128233 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Menarche (age at onset) ( 25231870 ) Serum immune biomarker levels ( 32066700 )	Breast cancer in childhood cancer survivors ( 29059430 ) Breast cancer in childhood cancer survivors treated with less than 10 gray radiotherapy ( 29059430 ) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821 ) Interleukin-6 levels in HIV infection ( 33095540 ) Refractive error ( 32231278 )
Interacting Genes		79 interacting genes: ACTN4 ACVR1 ANKRD11 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 NTAQ1 OTUD4 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PRKN PSMC5 RB1 RNF14 RPS6KC1 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TDG TRIM24 TRIP13 UBR5 ZBTB16	5 interacting genes: PBX2 PRDX3 SAAL1 SPHK1 VDR
Entrez ID		7421	26750
HPRD ID		03463	10204
Ensembl ID		ENSG00000111424	ENSG00000136643
Uniprot IDs		A0A5K1VW50 F1D8P8 P11473	A0A087X1U5 F5H7T0 F6RJM5 Q96S38
PDB IDs		1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2 7QPP 8IQN 8IQT	Not available
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nuclear Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Retinoic Acid Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Hormone-mediated Signaling Pathway Transcription Coactivator Activity Transcription Corepressor Activity Nucleobase-containing Compound Biosynthetic Process DNA-binding Transcription Factor Binding Intracellular Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription	Maternal Process Involved In Female Pregnancy Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Regulation Of Cell Population Proliferation Lithocholic Acid Binding Sphingoid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Reactive Oxygen Species Response To Hydrogen Peroxide Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Endosomal Vesicle Fusion NADH-dependent Peroxiredoxin Activity Apoptotic Process Involved In Mammary Gland Involution Vitamin D Response Element Binding Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Sphingosine Kinase Activity Regulation Of DNA-binding Transcription Factor Activity Response To Reactive Oxygen Species Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Vitamin D Binding Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Sphingolipid Biosynthetic Process Lipid Kinase Activity Cellular Response To Oxidative Stress Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Brain Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis Positive Regulation Of Apoptotic Process Involved In Development Cellular Response To Chemical Stress Regulation Of Phosphate Transport Sphingosine-1-phosphate Receptor Activity Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Maternal Placenta Development Phosphate Ion Transmembrane Transport Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Programmed Cell Death Nuclear Retinoid X Receptor Binding