VDR and HR

Number of citations of the paper that reports this interaction (PubMedID 20512927)
50

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		VDR	HR
Description		vitamin D receptor	HR lysine demethylase and nuclear receptor corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Vitamin D Binding Protein Binding Zinc Ion Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Histone H3K9me/H3K9me2 Demethylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Skeletal System Development Regulation Of DNA-templated Transcription Calcium Ion Transport Intracellular Calcium Ion Homeostasis Lactation Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Phosphate Ion Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway MRNA Transcription By RNA Polymerase II Cell-cell Junction Maintenance Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Retinoic Acid Receptor Signaling Pathway Intestinal Absorption Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Negative Regulation Of Phosphate Transmembrane Transport	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs		Calcitriol Calcifediol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol Lexacalcitol Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Elocalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin Curcumin sulfate
Diseases		Tuberculosis Localized autosomal recessive hypotrichosis	Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH) Atrichia with papular lesions
GWAS		Asthma (adult onset) ( 31036433) Basal cell carcinoma ( 33549134) Eosinophil percentage of white cells ( 32888494) Gout ( 22179738) Gut microbiota (beta diversity) ( 27723756) Inflammatory bowel disease ( 23128233) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Menarche (age at onset) ( 25231870) Serum immune biomarker levels ( 32066700)	Obesity-related traits ( 23251661)
Interacting Genes		79 interacting genes: ACTN4 ACVR1 ANKRD11 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 NTAQ1 OTUD4 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PRKN PSMC5 RB1 RNF14 RPS6KC1 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TDG TRIM24 TRIP13 UBR5 ZBTB16	35 interacting genes: ACTMAP AMMECR1 ATP23 CFAP68 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12
Entrez ID		7421	55806
HPRD ID		03463	03808
Ensembl ID		ENSG00000111424	ENSG00000168453
Uniprot IDs		A0A5K1VW50 F1D8P8 P11473	O43593
PDB IDs		1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2 7QPP 8IQN 8IQT
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nuclear Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Retinoic Acid Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Hormone-mediated Signaling Pathway Transcription Coactivator Activity Transcription Corepressor Activity Nucleobase-containing Compound Biosynthetic Process DNA-binding Transcription Factor Binding Intracellular Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription	Histone Deacetylase Activity, Hydrolytic Mechanism Intermediate Filament Histone Deacetylase Complex Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Transcription Repressor Complex Protein Lysine Delactylase Activity Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Glandular Epithelial Cell Development Keratin Filament Cardiac Muscle Cell Differentiation Negative Regulation Of Cytokine Production Ventricular Cardiac Muscle Cell Differentiation Nuclear Receptor-mediated Signaling Pathway Heterocyclic Compound Binding Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Cardiocyte Differentiation Transcription Corepressor Binding Histone Deacetylase Binding Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Growth Plate Cartilage Development Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Protein Deacetylation Positive Regulation Of RNA Biosynthetic Process Hippocampus Development Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription Striated Muscle Cell Differentiation Columnar/cuboidal Epithelial Cell Development Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Structural Molecule Activity Nuclear Retinoid X Receptor Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Regulation Of Striated Muscle Cell Differentiation Apoptotic Cell Clearance
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