VDR and ACVR1

Number of citations of the paper that reports this interaction (PMID 9267036)
316

Data Source:
HPRD (two hybrid, in vitro)

		VDR	ACVR1
Gene Name		vitamin D (1,25- dihydroxyvitamin D3) receptor	activin A receptor, type I
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex	Integral Component Of Plasma Membrane Apical Part Of Cell Activin Receptor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Calcitriol Receptor Activity Lithocholic Acid Receptor Activity Sequence-specific DNA Binding Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Skeletal System Development Transcription Initiation From RNA Polymerase II Promoter Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Lactation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Decidualization Intestinal Absorption Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Calcidiol 1-monooxygenase Activity Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Patterning Of Blood Vessels Urogenital System Development In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Mitral Valve Morphogenesis Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Tissue Development Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		Calcitriol Calcidiol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol 1alpha,25-Dihydroxyl-20-Epi-22-Oxa-24,26,27-Trihomovitamin D3 Seocalcitol Inecalcitol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)	Adenosine triphosphate 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		71 interactors: ACTN4 ACVR1 BAG1 CASC4 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 EIF3I FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MMRN2 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TCF3 TDG TRIM24 ZBTB16	64 interactors: AP2B1 BAMBI BMP2 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FCHO1 FGD6 FKBP4 FNTA GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61
Entrez ID		7421	90
HPRD ID		03463	00021
Ensembl ID		ENSG00000111424	ENSG00000115170
Uniprot IDs		F1D8P8 P11473	D3DPA4 Q04771
PDB IDs		1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 4G2I	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Cell Communication Anatomical Structure Development Signal Transduction Cellular Response To Stimulus Response To Hormone Cellular Metabolic Process Signaling Multicellular Organismal Development Response To Organic Substance	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Intracellular Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Metabolic Process Response To Stimulus BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cell Differentiation Regulation Of Cellular Process Ras Protein Signal Transduction Anatomical Structure Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Skeletal System Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Response To Organic Substance Positive Regulation Of Gene Expression Epithelium Development Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation
Tagcloud ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Difference) ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Intersection) ?