VDR and RXRB

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid)

		VDR	RXRB
Gene Name		vitamin D (1,25- dihydroxyvitamin D3) receptor	retinoid X receptor, beta
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Calcitriol Receptor Activity Lithocholic Acid Receptor Activity Sequence-specific DNA Binding Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity 9-cis Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Skeletal System Development Transcription Initiation From RNA Polymerase II Promoter Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Lactation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Decidualization Intestinal Absorption Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Calcidiol 1-monooxygenase Activity Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway	In Utero Embryonic Development Maternal Placenta Development Transcription Initiation From RNA Polymerase II Promoter Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Retinoic Acid
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs		Calcitriol Calcidiol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol 1alpha,25-Dihydroxyl-20-Epi-22-Oxa-24,26,27-Trihomovitamin D3 Seocalcitol Inecalcitol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)	Adapalene Bexarotene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE N-(TERT-BUTYL)-3,5-DIMETHYL-N\'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		71 interactors: ACTN4 ACVR1 BAG1 CASC4 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 EIF3I FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MMRN2 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TCF3 TDG TRIM24 ZBTB16	32 interactors: AKAP13 CACNA1B GRIP1 GTF2H1 MAP4 MED1 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PPARD PPARG PTMS RARA RARB RARG SPOP SRA1 SRC TACC2 TAF11 THRA THRB VDR ZDHHC12
Entrez ID		7421	6257
HPRD ID		03463	01578
Ensembl ID		ENSG00000111424	ENSG00000204231
Uniprot IDs		F1D8P8 P11473	E9PK95 P28702 Q5STP9
PDB IDs		1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 4G2I	1H9U 1UHL
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Cell Communication Anatomical Structure Development Signal Transduction Cellular Response To Stimulus Response To Hormone Cellular Metabolic Process Signaling Multicellular Organismal Development Response To Organic Substance	Intracellular Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Cellular Response To Hormone Stimulus Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Hormone Positive Regulation Of Cellular Biosynthetic Process Response To Lipid Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death
Tagcloud ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10	2riibp aa acceptor bands cdnas coding cpg deduced designated exons extra finger heterodimers intron island isoforms midst mrxr northern phylogenic spleen spliced splicing superfamily transactivation transcribed twofold zinc
Tagcloud (Difference) ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10	2riibp aa acceptor bands cdnas coding cpg deduced designated exons extra finger heterodimers intron island isoforms midst mrxr northern phylogenic spleen spliced splicing superfamily transactivation transcribed twofold zinc
Tagcloud (Intersection) ?