VDR and MED14

Number of citations of the paper that reports this interaction (PMID 10235266)
164

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		VDR	MED14
Gene Name		vitamin D (1,25- dihydroxyvitamin D3) receptor	mediator complex subunit 14
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Calcitriol Receptor Activity Lithocholic Acid Receptor Activity Sequence-specific DNA Binding Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Skeletal System Development Transcription Initiation From RNA Polymerase II Promoter Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Lactation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Decidualization Intestinal Absorption Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Calcidiol 1-monooxygenase Activity Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs		Calcitriol Calcidiol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol 1alpha,25-Dihydroxyl-20-Epi-22-Oxa-24,26,27-Trihomovitamin D3 Seocalcitol Inecalcitol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		71 interactors: ACTN4 ACVR1 BAG1 CASC4 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 EIF3I FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MMRN2 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TCF3 TDG TRIM24 ZBTB16	20 interactors: ACTN1 ACTN2 AR CTDP1 DCTN1 ESR1 ESR2 HNF4A MED1 MED29 MED9 MYC NECAB2 NR3C1 PARP1 PPARGC1A SREBF1 STAT2 UACA VDR
Entrez ID		7421	9282
HPRD ID		03463	02172
Ensembl ID		ENSG00000111424	ENSG00000180182
Uniprot IDs		F1D8P8 P11473	O60244
PDB IDs		1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 4G2I
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Cell Communication Anatomical Structure Development Signal Transduction Cellular Response To Stimulus Response To Hormone Cellular Metabolic Process Signaling Multicellular Organismal Development Response To Organic Substance	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Lipid Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Steroid Hormone Mediated Signaling Pathway RNA Metabolic Process Regulation Of Metabolic Process Response To Hormone Gene Expression Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Response To Steroid Hormone Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Mammary Gland Branching Involved In Pregnancy Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Regulation Of Apoptotic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cell Death Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Gland Morphogenesis Positive Regulation Of Metabolic Process Mammary Gland Duct Morphogenesis Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated
Tagcloud ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10	bridges cha1 eliminated eukaryotes gal11 kin28 machinery med15 med17 med18 mediator module modules paf1 rbp1 recruitment remodeling rgr1 ser2 ser5 severely snf srb4 srb5 swi tata tbp ts unaffected
Tagcloud (Difference) ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10	bridges cha1 eliminated eukaryotes gal11 kin28 machinery med15 med17 med18 mediator module modules paf1 rbp1 recruitment remodeling rgr1 ser2 ser5 severely snf srb4 srb5 swi tata tbp ts unaffected
Tagcloud (Intersection) ?