LAX1 and GRAP2

Number of citations of the paper that reports this interaction (PMID 12359715)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LAX1	GRAP2
Gene Name		lymphocyte transmembrane adaptor 1	GRB2-related adaptor protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Membrane Raft	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding SH2 Domain Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Inactivation Of MAPK Activity Immune Response Intracellular Signal Transduction B Cell Activation Immunoglobulin Secretion Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Activation	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response T Cell Receptor Signaling Pathway
Pathways			DAP12 interactions Generation of second messenger molecules Costimulation by the CD28 family CD28 co-stimulation FCERI mediated MAPK activation Signaling by SCF-KIT DAP12 signaling TCR signaling Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: GRAP2 GRB2 GRB7 LCK NDN STAMBPL1 SYK ZAP70	31 interactors: BEND5 BLNK CCNDBP1 CD28 CSF1R ERBB2 FASLG GAB1 GAB2 GAB3 GFAP GNB2L1 HNRNPK KHDRBS1 KIT KRTAP4-12 LAT LAX1 LCP2 MAP4K1 PRPH2 RBPMS SHB SHC1 SOS2 SPRY2 STAMBP UBC USP8 YWHAE ZBTB7B
Entrez ID		54900	9402
HPRD ID		08312	05156
Ensembl ID		ENSG00000122188	ENSG00000100351
Uniprot IDs		Q8IWV1	B7Z8E3 B7Z8F8 F5H548 O75791 Q6FI14
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cell Migration Regulation Of Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Beta Selection Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component T Cell Costimulation Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Immune System Process Positive Regulation Of Gamma-delta T Cell Activation Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Immune System Process Regulation Of Lymphocyte Differentiation T Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Body Fluid Levels Immune Response Regulation Of Immune System Process	Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Response To Growth Factor Regulation Of MAP Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cellular Response To Stimulus Phosphatidylinositol-mediated Signaling Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Immune Response Immune System Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Response To Stimulus Regulation Of Phosphorylation
Tagcloud ?			a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined
Tagcloud (Difference) ?			a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined
Tagcloud (Intersection) ?