LAX1 and GRB7

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LAX1	GRB7
Gene Name		lymphocyte transmembrane adaptor 1	growth factor receptor-bound protein 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Membrane Raft	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection
	Molecular Function	Protein Binding Protein Kinase Binding SH2 Domain Binding	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Inactivation Of MAPK Activity Immune Response Intracellular Signal Transduction B Cell Activation Immunoglobulin Secretion Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Activation	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration
Pathways			Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: GRAP2 GRB2 GRB7 LCK NDN STAMBPL1 SYK ZAP70	39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16
Entrez ID		54900	2886
HPRD ID		08312	03311
Ensembl ID		ENSG00000122188	ENSG00000141738
Uniprot IDs		Q8IWV1	Q14451
PDB IDs			1MW4 1WGR 2L4K 2QMS 3PQZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cell Migration Regulation Of Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Beta Selection Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component T Cell Costimulation Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Immune System Process Positive Regulation Of Gamma-delta T Cell Activation Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Immune System Process Regulation Of Lymphocyte Differentiation T Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Body Fluid Levels Immune Response Regulation Of Immune System Process	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Difference) ?			adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Intersection) ?