LAX1 and GRB7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LAX1	GRB7
Description		lymphocyte transmembrane adaptor 1	growth factor receptor bound protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Membrane Membrane Raft	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Protein Kinase Binding SH2 Domain Binding	RNA Binding Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Intracellular Signal Transduction B Cell Activation Negative Regulation Of MAPK Cascade Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Activation Regulation Of Lymphocyte Activation	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways			GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling RND1 GTPase cycle
Drugs
Diseases
GWAS		Malaria ( 31844061) Male-pattern baldness ( 28196072)	Asthma ( 28461288 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 20228799 28067908)
Interacting Genes		9 interacting genes: GRAP2 GRB2 GRB7 IDH1 LCK NDN STAMBPL1 SYK ZAP70	54 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1
Entrez ID		54900	2886
HPRD ID		08312	03311
Ensembl ID		ENSG00000122188	ENSG00000141738
Uniprot IDs		Q8IWV1	A0A0S2Z4F6 Q14451
PDB IDs			1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q 7MP3
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Beta Selection Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity B Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Gamma-delta T Cell Differentiation T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Immune Response-activating Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cytosol Positive Regulation Of T Cell Differentiation Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Lymphocyte Differentiation T Cell Receptor Complex Gamma-delta T Cell Activation Phospholipase Binding Protein Kinase Binding Lymphocyte Activation T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation T Cell Selection Regulation Of T Cell Differentiation Positive Regulation Of Leukocyte Differentiation Leukocyte Activation Regulation Of Signal Transduction Cell-cell Junction Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Lymphocyte Differentiation	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Receptor Complex Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase Activity Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Regulation Of Cell Adhesion Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process ERBB2 Signaling Pathway Transferase Activity Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Positive Regulation Of Protein Modification Process Cellular Developmental Process Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Regulation Of Receptor Signaling Pathway Via JAK-STAT Nucleotide Binding ATP Binding Regulation Of Locomotion Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction Regulation Of Developmental Process
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