LAX1 and STAMBPL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LAX1	STAMBPL1
Description		lymphocyte transmembrane adaptor 1	STAM binding protein like 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Membrane Membrane Raft	Endosome Cytosol Membrane
	Molecular Function	Protein Binding Protein Kinase Binding SH2 Domain Binding	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Intracellular Signal Transduction B Cell Activation Negative Regulation Of MAPK Cascade Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Activation Regulation Of Lymphocyte Activation	Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Protein K63-linked Deubiquitination Cellular Response To L-leucine Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways			Metalloprotease DUBs
Drugs
Diseases
GWAS		Malaria ( 31844061) Male-pattern baldness ( 28196072)
Interacting Genes		9 interacting genes: GRAP2 GRB2 GRB7 IDH1 LCK NDN STAMBPL1 SYK ZAP70	38 interacting genes: A2M BIRC5 CALCOCO2 CDC37 CEP72 COPS5 COPS6 DUSP1 ECSIT ENOX2 GCSAML GNPTAB GOLGA2 GOLGA6L9 IKZF3 INCA1 LAX1 LCOR MAGEA6 MAST1 MORN5 PLEKHF2 PNMA1 PSEN1 RAB2A RAB2B REL RNF32 SESN2 SF3B5 SMAD2 SMAD7 TCF4 TRIM27 TRIP13 UBC ZNF835 ZRANB1
Entrez ID		54900	57559
HPRD ID		08312	16486
Ensembl ID		ENSG00000122188	ENSG00000138134
Uniprot IDs		Q8IWV1	Q96FJ0
PDB IDs			2ZNR 2ZNV 7L97
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Beta Selection Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity B Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Gamma-delta T Cell Differentiation T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Immune Response-activating Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cytosol Positive Regulation Of T Cell Differentiation Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Lymphocyte Differentiation T Cell Receptor Complex Gamma-delta T Cell Activation Phospholipase Binding Protein Kinase Binding Lymphocyte Activation T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation T Cell Selection Regulation Of T Cell Differentiation Positive Regulation Of Leukocyte Differentiation Leukocyte Activation Regulation Of Signal Transduction Cell-cell Junction Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Lymphocyte Differentiation
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