LAX1 and IDH1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
45

Data Source:
BioGRID (two hybrid)

		LAX1	IDH1
Description		lymphocyte transmembrane adaptor 1	isocitrate dehydrogenase (NADP(+)) 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Membrane Membrane Raft	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Protein Kinase Binding SH2 Domain Binding	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding NADP Binding NAD Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Intracellular Signal Transduction B Cell Activation Negative Regulation Of MAPK Cascade Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Activation Regulation Of Lymphocyte Activation	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP+ Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways			Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import NFE2L2 regulating TCA cycle genes
Drugs			Isocitric Acid Nicotinamide adenine dinucleotide phosphate Ivosidenib Olutasidenib
Diseases
GWAS		Malaria ( 31844061) Male-pattern baldness ( 28196072)	Adult diffuse glioma (IDH mutation) ( 32386320) Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)
Interacting Genes		9 interacting genes: GRAP2 GRB2 GRB7 IDH1 LCK NDN STAMBPL1 SYK ZAP70	19 interacting genes: AGGF1 CALM1 CDK1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 FILNC1 LAX1 LINC01554 NUP62 PEX5 PLK1 PRDM14 SUMO4 TMOD4 UBL7 ZHX1
Entrez ID		54900	3417
HPRD ID		08312	00984
Ensembl ID		ENSG00000122188	ENSG00000138413
Uniprot IDs		Q8IWV1	A0A024R3Y6 O75874
PDB IDs			1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F 6U4J 6VEI 6VG0 7PJM 7PJN 8BAY 8HB9 8T7D 8T7N 8T7O 8VH9 8VHA 8VHB 8VHC 8VHD 8VHE
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Beta Selection Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity B Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Gamma-delta T Cell Differentiation T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Immune Response-activating Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cytosol Positive Regulation Of T Cell Differentiation Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Lymphocyte Differentiation T Cell Receptor Complex Gamma-delta T Cell Activation Phospholipase Binding Protein Kinase Binding Lymphocyte Activation T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation T Cell Selection Regulation Of T Cell Differentiation Positive Regulation Of Leukocyte Differentiation Leukocyte Activation Regulation Of Signal Transduction Cell-cell Junction Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Lymphocyte Differentiation	Spindle Microtubule Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle Centrosome Cycle Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Centrosome Separation Regulation Of Cytokinesis Nuclear Membrane Disassembly Microtubule Organizing Center Organization Membrane Disassembly Protein Localization To Site Of Double-strand Break Mitotic Cell Cycle Phase Transition Regulation Of Cell Division Spindle Pole Cell Cycle Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Pronuclear Fusion Cardiac Muscle Cell Development Chromosome Condensation Cardiac Cell Development Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Organization SH2 Domain Binding Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Methyltransferase Regulator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Spindle Negative Regulation Of Apoptotic Process Mitotic DNA-templated DNA Replication Post-translational Protein Modification Nuclear Membrane Organization Cellular Response To Oxidative Stress Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Mitotic G2/M Transition Checkpoint Cyclin A2-CDK1 Complex Hsp70 Protein Binding Negative Regulation Of DNA-templated Transcription Atrial Cardiac Muscle Cell Development Negative Regulation Of RNA Biosynthetic Process Synaptonemal Complex Disassembly Golgi Inheritance Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Negative Regulation Of Programmed Cell Death Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Chemical Stress
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