HIVEP1 and APTX

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HIVEP1	APTX
Description		HIVEP zinc finger 1	aprataxin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Catalytic Activity Protein Binding Zinc Ion Binding Phosphoglycolate Phosphatase Activity Hydrolase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Phosphoprotein Binding DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Single Strand Break Repair DNA Repair DNA Damage Response Regulation Of Protein Stability
Pathways
Drugs
Diseases			Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Coenzyme Q10 deficiency
GWAS		Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 22488850) Asthma ( 32296059) Body mass index ( 25673413 28892062 29273807) Chronotype ( 30696823) Feeling worry ( 29500382) Figural/spatial cognitive ability ( 31620175) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Takayasu arteritis ( 25604533)	Height ( 28552196) Menopause (age at onset) ( 26414677)
Interacting Genes		72 interacting genes: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BANP BHLHE40 BNIP3 BRCA1 CACNA1A CCNK CDC37 CLK1 CREB1 CREBBP DNAJA1 ELOA EMG1 FXR1 FXR2 GAA GSDMB HPD HSPA1A IGFN1 IMMT KDF1 MAGED1 MAPK14 MAPK8 MIEN1 MTMR3 NINJ1 NLGN3 NRF1 NUCB1 OGT OTX1 PLEKHB2 POGZ POU2F1 POU6F2 PRKAR1A PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAB1A RBM47 RBPMS RIDA RNF186 ROR2 SDCBP SERTAD1 SH3KBP1 SMAD3 SNX4 SOCS3 SOX10 SP4 SRPK2 STAT3 TENT5B TMEM176A VCF2 VEZF1 ZC3H10 ZFHX3	18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639
Entrez ID		3096	54840
HPRD ID		01925	05892
Ensembl ID		ENSG00000095951	ENSG00000137074
Uniprot IDs		A0A0D9SFF3 A0AAQ5BHS1 H7BYU7 P15822	A0A5K1VW64 Q7Z2E3
PDB IDs		1BBO 3ZNF 4ZNF	3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Stability Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Chromatin Regulation Of Developmental Process Regulation Of Biological Quality Transcription By RNA Polymerase II Pyroptotic Inflammatory Response Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Enzyme Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Regulation Of Multicellular Organismal Process Rhythmic Process DNA-binding Transcription Factor Activity POZ Domain Binding Regulation Of Circadian Rhythm Positive Regulation Of MRNA Catabolic Process Regulation Of RNA Splicing MRF Binding C3HC4-type RING Finger Domain Binding Regulation Of MiRNA-mediated Gene Silencing	Negative Regulation Of Telomere Maintenance Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Mitochondrial DNA Repair Nucleolus Enzyme Binding Positive Regulation Of Programmed Necrotic Cell Death Regulation Of Cellular Component Organization Double-strand Break Repair Negative Regulation Of Chromosome Organization Chromatin Binding Site Of Double-strand Break Mitochondrial DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of Catalytic Activity Protein Localization To Organelle Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Protein Localization To Site Of Double-strand Break Response To X-ray Negative Regulation Of DNA Replication NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Regulation Of Programmed Necrotic Cell Death NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Site Of DNA Damage NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of Metalloendopeptidase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Cell Growth Base-excision Repair Oxidized DNA Binding FHA Domain Binding FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity Cellular Response To Glucose Starvation Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Regulation Of DNA Metabolic Process Positive Regulation Of Myofibroblast Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity DNA Repair
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?