HIVEP1 and NUCB1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HIVEP1	NUCB1
Description		HIVEP zinc finger 1	nucleobindin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Small GTPase-mediated Signal Transduction
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 22488850) Asthma ( 32296059) Body mass index ( 25673413 28892062 29273807) Chronotype ( 30696823) Feeling worry ( 29500382) Figural/spatial cognitive ability ( 31620175) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Takayasu arteritis ( 25604533)
Interacting Genes		72 interacting genes: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BANP BHLHE40 BNIP3 BRCA1 CACNA1A CCNK CDC37 CLK1 CREB1 CREBBP DNAJA1 ELOA EMG1 FXR1 FXR2 GAA GSDMB HPD HSPA1A IGFN1 IMMT KDF1 MAGED1 MAPK14 MAPK8 MIEN1 MTMR3 NINJ1 NLGN3 NRF1 NUCB1 OGT OTX1 PLEKHB2 POGZ POU2F1 POU6F2 PRKAR1A PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAB1A RBM47 RBPMS RIDA RNF186 ROR2 SDCBP SERTAD1 SH3KBP1 SMAD3 SNX4 SOCS3 SOX10 SP4 SRPK2 STAT3 TENT5B TMEM176A VCF2 VEZF1 ZC3H10 ZFHX3	18 interacting genes: DYRK1A GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 HOXA1 MYC NDN PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1
Entrez ID		3096	4924
HPRD ID		01925	03205
Ensembl ID		ENSG00000095951	ENSG00000104805
Uniprot IDs		A0A0D9SFF3 A0AAQ5BHS1 H7BYU7 P15822	A8K7Q1 Q02818
PDB IDs		1BBO 3ZNF 4ZNF	1SNL
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Stability Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Chromatin Regulation Of Developmental Process Regulation Of Biological Quality Transcription By RNA Polymerase II Pyroptotic Inflammatory Response Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Enzyme Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Regulation Of Multicellular Organismal Process Rhythmic Process DNA-binding Transcription Factor Activity POZ Domain Binding Regulation Of Circadian Rhythm Positive Regulation Of MRNA Catabolic Process Regulation Of RNA Splicing MRF Binding C3HC4-type RING Finger Domain Binding Regulation Of MiRNA-mediated Gene Silencing	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTP Binding Cyclooxygenase Pathway Prostaglandin-endoperoxide Synthase Activity Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion G Protein Activity Negative Regulation Of Protein Secretion Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Negative Regulation Of Transport Dioxygenase Activity Regulation Of Protein Transport Cell Body Negative Regulation Of Cell Communication Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Interferon-beta Production Prostaglandin Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Regulation Of Protein Secretion Prostanoid Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Macromolecule Biosynthetic Process G Protein-coupled Dopamine Receptor Signaling Pathway Protein-DNA Complex Disassembly Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Transport Regulation Of Secretion By Cell Response To Prostaglandin E
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