HIVEP1 and HPD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HIVEP1	HPD
Description		HIVEP zinc finger 1	4-hydroxyphenylpyruvate dioxygenase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Body	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	4-hydroxyphenylpyruvate Dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Aromatic Amino Acid Metabolic Process
Pathways			Tyrosine catabolism
Drugs			Nitisinone DAS869
Diseases			Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 22488850) Asthma ( 32296059) Body mass index ( 25673413 28892062 29273807) Chronotype ( 30696823) Feeling worry ( 29500382) Figural/spatial cognitive ability ( 31620175) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Takayasu arteritis ( 25604533)	HDL cholesterol levels ( 32203549) Obesity-related traits ( 23251661) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 21572414 26352407)
Interacting Genes		72 interacting genes: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BANP BHLHE40 BNIP3 BRCA1 CACNA1A CCNK CDC37 CLK1 CREB1 CREBBP DNAJA1 ELOA EMG1 FXR1 FXR2 GAA GSDMB HPD HSPA1A IGFN1 IMMT KDF1 MAGED1 MAPK14 MAPK8 MIEN1 MTMR3 NINJ1 NLGN3 NRF1 NUCB1 OGT OTX1 PLEKHB2 POGZ POU2F1 POU6F2 PRKAR1A PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAB1A RBM47 RBPMS RIDA RNF186 ROR2 SDCBP SERTAD1 SH3KBP1 SMAD3 SNX4 SOCS3 SOX10 SP4 SRPK2 STAT3 TENT5B TMEM176A VCF2 VEZF1 ZC3H10 ZFHX3	5 interacting genes: CDKN1A HIVEP1 IKBKG RIDA STK33
Entrez ID		3096	3242
HPRD ID		01925	02041
Ensembl ID		ENSG00000095951	ENSG00000158104
Uniprot IDs		A0A0D9SFF3 A0AAQ5BHS1 H7BYU7 P15822	P32754
PDB IDs		1BBO 3ZNF 4ZNF	3ISQ 5EC3 8IM2 8IM3
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Stability Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Chromatin Regulation Of Developmental Process Regulation Of Biological Quality Transcription By RNA Polymerase II Pyroptotic Inflammatory Response Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Enzyme Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Regulation Of Multicellular Organismal Process Rhythmic Process DNA-binding Transcription Factor Activity POZ Domain Binding Regulation Of Circadian Rhythm Positive Regulation Of MRNA Catabolic Process Regulation Of RNA Splicing MRF Binding C3HC4-type RING Finger Domain Binding Regulation Of MiRNA-mediated Gene Silencing	Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Proliferation Cyclin Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Cyclin D2-CDK6 Complex Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Damage Checkpoint Signaling 2-iminopropanoate Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase L-threonine Catabolic Process To Glycine RNA Endonuclease Activity Producing 3'-phosphomonoesters, Hydrolytic Mechanism 2-iminobutanoate Deaminase Activity Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cyclin D3-CDK6 Complex Regulation Of Fibroblast Proliferation Cyclin D1-CDK6 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle FBXO Family Protein Binding PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration DNA Damage Checkpoint Signaling L-threonine Catabolic Process Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Linear Polyubiquitin Binding Threonine Metabolic Process Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cellular Response To Cell-matrix Adhesion Positive Regulation Of Metabolic Process Gliogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Negative Regulation Of Mitotic Cell Cycle IkappaB Kinase Complex Manchette Assembly Negative Regulation Of Cell Cycle Phase Transition Nucleus Deaminase Activity
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