CNTROB and TSHZ2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNTROB	TSHZ2
Description		centrobin, centriole duplication and spindle assembly protein	teashirt zinc finger homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Ciliary Basal Body	Chromatin Nucleus
	Molecular Function	Protein Binding Protein Domain Specific Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Centriole Replication Centrosome Separation Cell Division Regulation Of Cilium Assembly Mitotic Cytokinetic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression
Pathways
Drugs
Diseases
GWAS		Refractive error ( 32231278)	A body shape index ( 34021172) Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein A1 levels ( 32203549) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Coronary artery aneurysm in Kawasaki disease ( 27171184) Crohn's disease ( 32581322) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Hemoglobin ( 19862010) Hip index ( 34021172) Parkinson's disease ( 26227905) Spatial memory ( 31596458) Triglyceride levels ( 32203549) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Type 2 diabetes (age of onset) ( 28060188) Urinary metabolite levels in chronic kidney disease ( 29545352) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		20 interacting genes: APTX COASY CWF19L2 DAPK1 DUSP29 ELOA EPM2AIP1 GSK3A LYST MCRS1 PELI1 PNKP RAD23A RSPH14 SMARCA2 SYT6 TCEA2 TSC1 TSHZ2 TTC23	21 interacting genes: APBB1 BACH2 CCDC57 CCDC88B CNTROB COG3 CRACR2B GIGYF1 GOLGA2 GRIPAP1 MCC PHAF1 PIBF1 PNMA1 RABEP1 RINT1 SPTA1 TFIP11 TRAF1 TRAF2 UBE2I
Entrez ID		116840	128553
HPRD ID		13991	10730
Ensembl ID		ENSG00000170037	ENSG00000182463
Uniprot IDs		Q8N137	Q9NRE2
PDB IDs
Enriched GO Terms of Interacting Partners?		Polynucleotide 3'-phosphatase Activity DNA Metabolic Process DNA Repair Positive Regulation Of DNA Repair Damaged DNA Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of TOR Signaling Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair DNA Damage Response Positive Regulation Of DNA Metabolic Process Cellular Response To Stress DAPK1-calmodulin Complex Macromolecule Metabolic Process Positive Regulation Of Autophagic Cell Death Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Glycogen Metabolic Process Regulation Of TOR Signaling Regulation Of Glycogen Biosynthetic Process Response To Insulin Regulation Of Double-strand Break Repair Memory T Cell Differentiation DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Pantetheine-phosphate Adenylyltransferase Activity	Golgi Vesicle Transport Thioesterase Binding Microtubule Organizing Center Organization Cytoplasm Cellular Localization Microtubule Nucleation Establishment Of Protein Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membraneless Organelle Assembly Tumor Necrosis Factor Receptor Binding Centriole Assembly Centriole Replication
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