CMPK1

Description		cytidine/uridine monophosphate kinase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Nucleoside Diphosphate Kinase Activity Uridine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity UMP Kinase Activity CMP Kinase Activity DCMP Kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UMP Biosynthetic Process UDP Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion CDP Biosynthetic Process Nucleoside Monophosphate Phosphorylation Pyrimidine-containing Compound Biosynthetic Process
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Gemcitabine Cytidine-5'-Monophosphate Uridine-5'-Diphosphate P1-(adenosine-5'-P5-(uridine-5')pentaphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Corneal curvature ( 24963161) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: BACE1 CDC42 CIDEB SGTB TMEM132D
Entrez ID		51727
HPRD ID		18258
Ensembl ID		ENSG00000162368
Uniprot IDs		A0A494BXC7 P30085
PDB IDs		1TEV 7E9V
Enriched GO Terms of Interacting Partners?		Leading Edge Membrane Positive Regulation Of Lamellipodium Organization Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Nucleus Localization Positive Regulation Of Lamellipodium Assembly Heart Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Pinocytosis Dendritic Cell Migration Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Golgi Localization Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Cellular Localization Heart Contraction Endothelin Receptor Signaling Pathway Involved In Heart Process Cardiac Conduction System Development Embryonic Heart Tube Development Establishment Of Epithelial Cell Polarity Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Dendritic Spine Morphogenesis Dendrite Positive Regulation Of Filopodium Assembly Establishment Of Golgi Localization Dendritic Spine Organization Phagocytosis, Engulfment Neuronal Cell Body Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Neuropilin Signaling Pathway GBD Domain Binding Golgi Transport Complex Storage Vacuole Identical Protein Binding Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Spindle Midzone Supramolecular Fiber Organization Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Nuclear Migration Positive Regulation Of Programmed Cell Death Prepulse Inhibition
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