CDH15 and CDON

Number of citations of the paper that reports this interaction (PubMedID 12634428)
26

Data Source:
HPRD (in vivo)

		CDH15	CDON
Description		cadherin 15	cell adhesion associated, oncogene regulated
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Adherens Junction Membrane Catenin Complex Neuromuscular Junction Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding	Protein Binding Coreceptor Activity
	Biological Process	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Cell-cell Adhesion	Cell Fate Specification Positive Regulation Of Neuroblast Proliferation Lens Development In Camera-type Eye Cell Adhesion Smoothened Signaling Pathway Nervous System Development Neuroblast Proliferation Skeletal Muscle Tissue Development Myoblast Fusion Anterior/posterior Pattern Specification Embryonic Body Morphogenesis Skeletal Muscle Satellite Cell Differentiation Central Nervous System Neuron Differentiation Cerebral Cortex Development Neuron Differentiation Positive Regulation Of MAPK Cascade Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Cell Differentiation Embryonic Retina Morphogenesis In Camera-type Eye Neural Precursor Cell Proliferation Negative Regulation Of Biomineral Tissue Development Cellular Response To Vitamin D Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion
Pathways		Adherens junctions interactions Myogenesis Myogenesis	Myogenesis Myogenesis Ligand-receptor interactions Activation of SMO
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS			Alzheimer's disease (late onset) ( 22881374) Blood protein levels ( 30072576) Cerebral white matter volume ( 31530798) Height ( 31562340) Lung function (FEV1) ( 28166213) Mild to moderate chronic kidney disease ( 31178898) Primary tooth development (time to first tooth eruption) ( 23704328) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		12 interacting genes: ARVCF BOC CDH7 CDH9 CDON CTNNA1 CTNNB1 GNA12 JUP SGTA SGTB UBQLN2	5 interacting genes: ABL1 BOC CDH15 CDH2 CTNNB1
Entrez ID		1013	50937
HPRD ID		00225	16372
Ensembl ID		ENSG00000129910	ENSG00000064309
Uniprot IDs		P55291	A0A804HL16 Q4KMG0
PDB IDs			3D1M 3N1F 3N1Q
Enriched GO Terms of Interacting Partners?		Catenin Complex Cell-cell Adhesion Adherens Junction Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Junction Assembly Cell Adhesion Cadherin Binding Cell-cell Junction Organization TRC Complex Cell Junction Assembly Catenin-TCF7L2 Complex Cell-cell Adhesion Mediated By Cadherin Regulation Of Neuroblast Proliferation Neuroblast Proliferation Intercalated Disc Adherens Junction Organization Cell Junction Organization Zonula Adherens Flotillin Complex Alpha-catenin Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Beta-catenin Binding Plasma Membrane Epithelial Cell-cell Adhesion Positive Regulation Of ERAD Pathway Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development Anchoring Junction Regulation Of Skeletal Muscle Tissue Development Regulation Of ERAD Pathway Focal Adhesion Positive Regulation Of Neuroblast Proliferation Protein Targeting To ER Cell Migration Anatomical Structure Morphogenesis Establishment Of Protein Localization To Endoplasmic Reticulum Cell Morphogenesis Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Membrane Cell-cell Junction Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Striated Muscle Tissue Development Cellular Component Assembly Detection Of Mechanical Stimulus Regulation Of Muscle Organ Development Protein-DNA Complex	Cell-cell Adhesion Catenin Complex Cell-cell Adhesion Mediated By Cadherin Adherens Junction Organization Positive Regulation Of Blood Vessel Branching Cell Adhesion Detection Of Muscle Stretch Regulation Of Blood Vessel Branching Fascia Adherens Glial Cell Differentiation Alpha-catenin Binding Myoblast Proliferation Cell-cell Junction Assembly Synaptic Vesicle Clustering Cell-cell Junction Organization Adherens Junction Apicolateral Plasma Membrane Cell Morphogenesis Response To Muscle Stretch Telencephalon Development Positive Regulation Of Morphogenesis Of An Epithelium Neuroepithelial Cell Differentiation Cell Junction Assembly Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Synapse Organization T Cell Differentiation In Thymus Regulation Of Long-term Synaptic Potentiation Cell Migration Detection Of Mechanical Stimulus Intercalated Disc Thymus Development Cadherin Binding Regulation Of Wnt Signaling Pathway Regulation Of Morphogenesis Of A Branching Structure System Development Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Epithelial Cell Differentiation Enzyme Binding Positive Regulation Of Neuron Apoptotic Process Regulation Of Morphogenesis Of An Epithelium ERBB Signaling Pathway Protein Kinase Binding Protein Localization To Cytoplasmic Microtubule Plus-end Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of MAPK Cascade Cell Junction Organization Apical Part Of Cell Regulation Of Fibroblast Proliferation
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