HAUS1 and POLR3C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HAUS1	POLR3C
Description		HAUS augmin like complex subunit 1	RNA polymerase III subunit C
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule HAUS Complex Mitotic Spindle Microtubule	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytosol
	Molecular Function	Protein Binding	DNA Binding Single-stranded DNA Binding DNA-directed RNA Polymerase Activity Protein Binding
	Biological Process	Centrosome Cycle Regulation Of Microtubule Nucleation Spindle Assembly Cell Division	Immune System Process DNA-templated Transcription Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS
Interacting Genes		82 interacting genes: AK8 ARFIP2 ATP6V1D BFSP2 BLOC1S6 BORCS6 C3orf62 CAGE1 CBY2 CCDC136 CCDC57 CCHCR1 CDR2 CENPP CEP170P1 CEP44 CEP55 CEP57L1 CEP63 CEP70 DCTN2 DMD DTNBP1 FAM161B FGFR1OP2 GOLGA2 HGS HOOK2 IFIT3 IFT20 INCA1 KDM1A KIFC3 KRT1 KRT15 KRT18 KRT19 KRT3 KRT31 KRT38 KRT40 KXD1 LDOC1 LURAP1 MAD1L1 MAGEA6 MCM10 MCM3 MED4 MED7 MIPOL1 MTUS2 NDC80 NECAB2 NINL NUP54 NUP62 ODAD1 PDE4DIP PIBF1 PKN1 POLR3C SPAG5 SSC5D STX11 SYCE1 SYCE3 TEAD4 TFIP11 TFPT TRAF1 TRIM23 TRIM27 TRIM54 TRIM69 TSG101 TXN2 USHBP1 VPS37C VPS52 WASHC3 ZNF471	38 interacting genes: ANKRD23 APP CAMK2B CEP44 CEP63 COIL DISC1 ENKD1 GOLGA2 GTF3C4 HAUS1 INCA1 KATNBL1 KIAA0408 KLHL2 KPNA1 KPNA3 KPNA5 KPNA6 KRT75 LZTS1 NCKIPSD OGT PAX6 PICK1 PNMA5 POU6F2 PRDM16 RBBP8NL ROCK1 ROPN1 SP100 TNR TRAF2 TRIM27 UBXN1 VAX1 VRTN
Entrez ID		115106	10623
HPRD ID		16385	17880
Ensembl ID		ENSG00000152240	ENSG00000186141
Uniprot IDs		Q96CS2	Q9BUI4
PDB IDs		7SQK	2XUB 2XV4 5AFQ 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Centrosome Microtubule-based Process Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Cytoskeleton Organization Intermediate Filament Organization Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Organelle Assembly Intermediate Filament Identical Protein Binding Microtubule Organizing Center Organization Establishment Of Localization In Cell Supramolecular Fiber Organization Organelle Localization Intracellular Transport Centrosome Cycle Microtubule Binding Intracellular Protein Localization Protein Localization To Centrosome Metaphase Chromosome Alignment Cellular Component Assembly Protein Transport Cilium Organization Centriole Assembly Spindle Organization Cellular Localization Structural Molecule Activity Establishment Of Protein Localization Cilium Assembly Microtubule Establishment Of Organelle Localization Chromosome Localization BLOC-1 Complex Plasma Membrane Bounded Cell Projection Assembly Microtubule Cytoskeleton Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Projection Assembly Mitotic Metaphase Chromosome Alignment Protein Localization To Cytoskeleton Spindle Pole Structural Constituent Of Cytoskeleton Vesicle Organization Centriole Centriole Replication Protein Localization To Organelle Endosomal Transport	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Spindle Pole Regulation Of Synapse Organization Microtubule-based Process Regulation Of Postsynapse Organization Negative Regulation Of Catabolic Process Regulation Of Synapse Maturation Viral Penetration Into Host Nucleus Microtubule Organizing Center Organization Cytoskeleton Organization Microtubule Cytoskeleton Organization Identical Protein Binding Protein Localization To Organelle Regulation Of Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Intracellular Transport Of Virus Regulation Of Neuroblast Proliferation Protein Import Into Nucleus Cytoplasm Centrosome Cycle Import Into Nucleus Host Cell Regulation Of Supramolecular Fiber Organization Cytoskeleton Postsynaptic Density Nucleoplasm Regulation Of Cell Junction Assembly Central Nervous System Development Membraneless Organelle Assembly Negative Regulation Of Neuroblast Proliferation Arp2/3 Complex Binding Regulation Of Synapse Assembly Centriole Cell Projection Organization Regulation Of Cellular Component Organization Negative Regulation Of Viral Transcription Negative Regulation Of Protein Ubiquitination Cytosol Organelle Organization Protein Localization To Nucleus Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organismal Process Regulation Of Amyloid-beta Clearance Organelle Assembly Regulation Of Viral Transcription TOR Signaling Chromatin DNA Binding
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