EXOC6 and ECSIT

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		EXOC6	ECSIT
Description		exocyst complex component 6	ECSIT signaling integrator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Plasma Membrane Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Flemming Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Protein Binding	Protein Binding Molecular Adaptor Activity
	Biological Process	Mitotic Cytokinesis Intracellular Protein Transport Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Membrane Fission Vesicle Tethering Involved In Exocytosis	Immune System Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitochondrial Respiratory Chain Complex I Assembly Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Age-related hearing impairment ( 34108613) Body mass index ( 28892062) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Glaucoma (primary open-angle) ( 29449654) Hemoglobin A1c levels ( 29403010) High density lipoprotein cholesterol levels ( 29403010 33339817) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 30054594) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Refractive error ( 32231278) Total bilirubin levels ( 29403010)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		11 interacting genes: APP CYP2C8 ECSIT EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32	53 interacting genes: A2M AIRIM AP1M2 APOE APP BFSP2 BLMH CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		54536	51295
HPRD ID		10216	12225
Ensembl ID		ENSG00000138190	ENSG00000130159
Uniprot IDs		A5YP36 B2RDH5 B3KXY5 B7Z6G5 E7EW84 Q8TAG9	Q9BQ95
PDB IDs
Enriched GO Terms of Interacting Partners?		Oxidoreductase Activity Removal Of Superoxide Radicals Regulation Of Extrinsic Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium Ion Transport Regulation Of Metal Ion Transport Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Glutaryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding Nitric-oxide Synthase Activity Cell Redox Homeostasis Smooth Muscle Hyperplasia Superoxide Metabolic Process Tetrahydrobiopterin Binding Cellular Oxidant Detoxification Negative Regulation Of Muscle Hyperplasia Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation Respiratory Burst Involved In Inflammatory Response Regulation Of Spontaneous Synaptic Transmission Regulation Of Calcium Ion Transmembrane Transport Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Monoatomic Ion Transport Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process	Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process Arachidonate Epoxygenase Activity Lipoprotein Particle Regulation Of MiRNA Metabolic Process Epoxygenase P450 Pathway NF-kappaB P50/p65 Complex Positive Regulation Of Protein Metabolic Process I-SMAD Binding Cellular Response To Interleukin-6 Cytoplasm Regulation Of Amyloid Fibril Formation Response To Interleukin-6 Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Astrocyte Activation Involved In Immune Response Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process Caffeine Oxidase Activity Magnesium Ion Binding Response To Virus Positive Regulation Of MiRNA Metabolic Process Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Regulation Of MiRNA Transcription Antiviral Innate Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Metabolic Process SMAD Protein Complex Neuronal Cell Body Protein Ubiquitination Oxidative Demethylation Retinoic Acid 4-hydroxylase Activity Heteromeric SMAD Protein Complex Cellular Response To Nicotine Protein Binding Innate Immune Response Cytosol Arachidonate Metabolic Process Omega-hydroxylase P450 Pathway Defense Response To Virus Defense Response To Tumor Cell Demethylation Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Glutamatergic Synapse
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