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EXOC6 and CYP2C8
Number of citations of the paper that reports this interaction (PMID
21163940
)
13
Data Source:
BioGRID
(two hybrid)
EXOC6
CYP2C8
Gene Name
exocyst complex component 6
cytochrome P450, family 2, subfamily C, polypeptide 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Exocyst
Cytosol
Plasma Membrane
Cytoplasm
Endoplasmic Reticulum Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Monooxygenase Activity
Iron Ion Binding
Arachidonic Acid Epoxygenase Activity
Steroid Hydroxylase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Oxygen Binding
Heme Binding
Caffeine Oxidase Activity
Aromatase Activity
Biological Process
Vesicle Docking Involved In Exocytosis
Organelle Organization
Protein Transport
Erythrocyte Differentiation
Cellular Protein Metabolic Process
Membrane Organization
Organic Acid Metabolic Process
Xenobiotic Metabolic Process
Drug Metabolic Process
Arachidonic Acid Metabolic Process
Epoxygenase P450 Pathway
Exogenous Drug Catabolic Process
Small Molecule Metabolic Process
Oxidation-reduction Process
Oxidative Demethylation
Omega-hydroxylase P450 Pathway
Pathways
Peptide hormone metabolism
Cargo trafficking to the periciliary membrane
Organelle biogenesis and maintenance
Translocation of GLUT4 to the plasma membrane
VxPx cargo-targeting to cilium
Assembly of the primary cilium
Insulin processing
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Arachidonic acid metabolism
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
CYP2E1 reactions
Biological oxidations
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Xenobiotics
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Immune response to smallpox vaccine (IL-6) (
22542470
)
Osteonecrosis of the jaw (
18594024
)
Response to clopidogrel therapy (
19706858
)
Warfarin maintenance dose (
23755828
)
Protein-Protein Interactions
11 interactors:
APP
CYP2C8
ECSIT
EXOSC1
GCDH
LOXL4
MAST1
NOS3
PRDX2
PSEN2
RNF32
11 interactors:
A2M
APOE
BLMH
DNAJB1
ECSIT
EXOC6
IFIT3
LONP1
MAST1
PSEN1
RNF32
Entrez ID
54536
1558
HPRD ID
10216
03083
Ensembl ID
ENSG00000138190
ENSG00000138115
Uniprot IDs
B3KXY5
E7EW84
F2Z2Q3
Q8TAG9
B7Z1F5
P10632
PDB IDs
1PQ2
2NNH
2NNI
2NNJ
2VN0
Enriched GO Terms of Interacting Partners
?
Oxidation-reduction Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Catabolic Process
Regulation Of Oxidoreductase Activity
Axon Guidance
Regulation Of ERBB Signaling Pathway
Smooth Muscle Hyperplasia
Synaptic Growth At Neuromuscular Junction
Reactive Oxygen Species Metabolic Process
Regulation Of Receptor Activity
Cellular Amino Acid Catabolic Process
Axonogenesis
Locomotion
Collateral Sprouting In Absence Of Injury
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Notch Signaling Pathway
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Protein Binding
Smooth Muscle Adaptation
Chemotaxis
Anatomical Structure Morphogenesis
Negative Regulation Of Muscle Hyperplasia
Collateral Sprouting
Regulation Of Systemic Arterial Blood Pressure By Endothelin
Axon Midline Choice Point Recognition
Neuron Projection Morphogenesis
Movement Of Cell Or Subcellular Component
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Axon Choice Point Recognition
Cell Morphogenesis Involved In Differentiation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Carboxylic Acid Catabolic Process
Regulation Of The Force Of Heart Contraction By Chemical Signal
Regulation Of Peptidyl-tyrosine Phosphorylation
Lysine Catabolic Process
Arginine Catabolic Process
Omega-hydroxylase P450 Pathway
Negative Regulation Of Cellular Protein Metabolic Process
Neuron Remodeling
Neuron Projection Development
Exit From Mitosis
Metabolic Process
Cell Projection Morphogenesis
Lung Development
Regulation Of Inclusion Body Assembly
Response To Stress
Protein Metabolic Process
Exocytosis
Oxidation-dependent Protein Catabolic Process
Cajal-Retzius Cell Differentiation
Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Positive Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Phospholipid Efflux
Negative Regulation Of Lipid Transport Across Blood Brain Barrier
Positive Regulation Of Lipid Transport Across Blood Brain Barrier
Beta-amyloid Formation
Positive Regulation Of Postsynaptic Membrane Organization
Negative Regulation Of Postsynaptic Membrane Organization
Regulation Of Oxidoreductase Activity
Response To Stimulus
Response To Oxidative Stress
Regulation Of Cellular Component Organization
Extracellular Matrix Disassembly
Establishment Of Localization In Cell
Positive Regulation Of Neurofibrillary Tangle Assembly
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Complement Activation, Lectin Pathway
Negative Regulation Of Presynaptic Membrane Organization
Positive Regulation Of Presynaptic Membrane Organization
Cellular Response To Stimulus
Secretion By Cell
Immune System Process
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Phospholipid Efflux
Negative Regulation Of Cholesterol Biosynthetic Process
Regulation Of Mitochondrial DNA Replication
Regulation Of Postsynaptic Membrane Organization
Very-low-density Lipoprotein Particle Clearance
Negative Regulation Of Cell Projection Organization
Regulation Of Catalytic Activity
Synaptic Vesicle Targeting
Regulation Of Resting Membrane Potential
Cellular Localization
Positive Regulation Of Cellular Protein Catabolic Process
Maintenance Of Location In Cell
Regulation Of Axonogenesis
Secretion
Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Regulation Of Tau-protein Kinase Activity
Response To Aluminum Ion
Negative Regulation Of Cholesterol Efflux
N-methyl-D-aspartate Receptor Clustering
Regulation Of Presynaptic Membrane Organization
Tagcloud
?
allele
apolipoprotein
associations
cardiotoxicity
commonly
comt
conform
epsilon4
failed
fatigue
genetic
genotype
guidelines
il6
impairment
listed
lle655val
met
neuropathy
polymorphisms
reporting
strega
systematic
toxicities
transparent
underlying
val
variant
variants
Tagcloud (Difference)
?
allele
apolipoprotein
associations
cardiotoxicity
commonly
comt
conform
epsilon4
failed
fatigue
genetic
genotype
guidelines
il6
impairment
listed
lle655val
met
neuropathy
polymorphisms
reporting
strega
systematic
toxicities
transparent
underlying
val
variant
variants
Tagcloud (Intersection)
?