EXOC6

Description		exocyst complex component 6
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Plasma Membrane Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Flemming Body
	Molecular Function	Protein Binding
	Biological Process	Mitotic Cytokinesis Intracellular Protein Transport Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Age-related hearing impairment ( 34108613) Body mass index ( 28892062) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Glaucoma (primary open-angle) ( 29449654) Hemoglobin A1c levels ( 29403010) High density lipoprotein cholesterol levels ( 29403010 33339817) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 30054594) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Refractive error ( 32231278) Total bilirubin levels ( 29403010)
Interacting Genes		11 interacting genes: APP CYP2C8 ECSIT EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32
Entrez ID		54536
HPRD ID		10216
Ensembl ID		ENSG00000138190
Uniprot IDs		A5YP36 B2RDH5 B3KXY5 B7Z6G5 E7EW84 Q8TAG9
PDB IDs
Enriched GO Terms of Interacting Partners?		Oxidoreductase Activity Removal Of Superoxide Radicals Regulation Of Extrinsic Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium Ion Transport Regulation Of Metal Ion Transport Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Glutaryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding Nitric-oxide Synthase Activity Cell Redox Homeostasis Smooth Muscle Hyperplasia Superoxide Metabolic Process Tetrahydrobiopterin Binding Cellular Oxidant Detoxification Negative Regulation Of Muscle Hyperplasia Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation Respiratory Burst Involved In Inflammatory Response Regulation Of Spontaneous Synaptic Transmission Regulation Of Calcium Ion Transmembrane Transport Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Monoatomic Ion Transport Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process
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