POU2F2 and PGR

Number of citations of the paper that reports this interaction (PubMedID 10480874)
0

Data Source:
BioGRID (pull down)

		POU2F2	PGR
Description		POU class 2 homeobox 2	progesterone receptor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Signaling Receptor Binding Steroid Binding Protein Binding Zinc Ion Binding Lipid Binding Enzyme Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding ATPase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus	Ovulation From Ovarian Follicle Epithelial Cell Maturation Glandular Epithelial Cell Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Mammary Gland Development Paracrine Signaling Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Regulation Of Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs			Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Eosinophil count ( 32888494) Meat-related diet ( 32066663) Monocyte count ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016)	Diastolic blood pressure ( 30224653) Length of menstrual cycle ( 30202859) Menarche (age at onset) ( 25231870) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		15 interacting genes: AR ESR1 GAPDH HMGA1 HMGB2 MNAT1 MSX2 NR2F1 NR3C1 PGR POU2AF1 RXRA TBP TXNRD1 XRCC6	55 interacting genes: ANP32A APEX2 ARID1A BATF3 BCAS2 BMI1 BRCA1 CCNA1 CCNA2 CDC25B CDK2 COPS5 CSNK2A1 CUEDC2 DAP3 DDX54 DNAJA1 DNAJC7 ESR1 FKBP5 HMGB1 HMGB2 HSP90AB1 HSPA1A JDP2 KAT2B KLF9 NCOA1 NCOA3 NR0B1 PIAS1 PIAS2 PIAS3 POU2F1 POU2F2 PRKDC PRMT2 RBM23 RBM39 RELA RNF4 SGTA SMARCD1 SMARCE1 SNW1 SORBS1 SRC TAF1B TDG TRIM24 UBE3A UBR5 XRCC5 XRCC6 ZBTB17
Entrez ID		5452	5241
HPRD ID		01251	07077
Ensembl ID		ENSG00000028277	ENSG00000082175
Uniprot IDs		A0A8I5KYI8 B5ME60 H0YLL6 P09086	P06401
PDB IDs		1HDP 9DZM	1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU 4OAR 5CC0
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Estrogen Response Element Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nuclear Steroid Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Steroid Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Hormone-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Enzyme Binding Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Transcription Regulator Complex Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Metabolic Process POU Domain Binding TFIIB-class Transcription Factor Binding Nucleoplasm Transcription Coregulator Binding	Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Organization Chromatin Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Stress Cellular Response To Hormone Stimulus Response To Hormone Nuclear Receptor Binding Macromolecule Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Regulation Of Cellular Response To Stress Nuclear Receptor-mediated Signaling Pathway Cellular Response To Oxygen-containing Compound Protein-containing Complex DNA Binding Cellular Response To Lipid Intracellular Receptor Signaling Pathway DNA Recombination Regulation Of DNA Metabolic Process
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