POU2F2 and TXNRD1

Number of citations of the paper that reports this interaction (PMID 10383413)
9

Data Source:
BioGRID (pull down)

		POU2F2	TXNRD1
Gene Name		POU class 2 homeobox 2	thioredoxin reductase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Domain Specific Binding Sequence-specific DNA Binding	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Mature B Cell Differentiation Immunoglobulin Secretion Involved In Immune Response Transcription From RNA Polymerase II Promoter Humoral Immune Response Positive Regulation Of Transcription, DNA-templated Cell Maturation	Response To Reactive Oxygen Species Signal Transduction Nucleobase-containing Small Molecule Interconversion Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Uptake and actions of bacterial toxins Metabolism of lipids and lipoproteins Detoxification of Reactive Oxygen Species Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Uptake and function of diphtheria toxin
Drugs			Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin-Adenine Dinucleotide Spermidine Fotemustine
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AR ESR1 GAPDH HMGA1 HMGB2 MNAT1 NR3C1 PGR POU2AF1 RXRA TBP TXNRD1 XRCC6	8 interactors: DMRTC2 FOXO1 GLRX2 POU2F1 POU2F2 PPP1R16A TXNDC17 TXNIP
Entrez ID		5452	7296
HPRD ID		01251	03068
Ensembl ID		ENSG00000028277	ENSG00000198431
Uniprot IDs		B5ME60 E9PNC9 P09086	B7Z1F4 B7Z2S5 B7Z904 E7EW10 Q16881
PDB IDs		1HDP	1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cellular Response To Steroid Hormone Stimulus RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Lipid Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Response To Steroid Hormone Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Reproductive Process Multicellular Organismal Reproductive Process Negative Regulation Of Biosynthetic Process Response To Lipid Multicellular Organism Reproduction Response To Organic Cyclic Compound Gland Development Reproductive Structure Development Reproductive System Development Mammary Gland Duct Morphogenesis Response To Hormone Prostate Gland Development	Response To Reactive Oxygen Species Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process Response To Oxidative Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Cellular Response To Tumor Cell Positive Regulation Of Histone H3-K9 Dimethylation Positive Regulation Of Histone H3-K9 Trimethylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Immunoglobulin Secretion Involved In Immune Response DNA Protection Response To Hydrogen Peroxide RNA Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Response To Temperature Stimulus Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Extracellular Stimulus Response To Tumor Cell Immunoglobulin Secretion Olfactory Placode Formation Cellular Response To Cold Spermatid Nucleus Elongation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Lens Induction In Camera-type Eye Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Energy Homeostasis Positive Regulation Of Cellular Metabolic Process Cellular Response To Nitric Oxide Response To Redox State Response To Nitric Oxide
Tagcloud ?		aberrations aggregate arid1a broaden carries constitutes deregulation disomy dnmt3b evolving exclusive exome fl follicular hist1h1 hodgkin implicating irf8 linker massively mutated mutually oct2 profiling recurrently stably substantially transduced uniparental	bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3
Tagcloud (Difference) ?		aberrations aggregate arid1a broaden carries constitutes deregulation disomy dnmt3b evolving exclusive exome fl follicular hist1h1 hodgkin implicating irf8 linker massively mutated mutually oct2 profiling recurrently stably substantially transduced uniparental	bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3
Tagcloud (Intersection) ?