MTREX and EXOSC9

Number of citations of the paper that reports this interaction (PubMedID 11719186)
0

Data Source:
HPRD (in vivo)

		MTREX	EXOSC9
Description		Mtr4 exosome RNA helicase	exosome component 9
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing MRNA Processing RNA Catabolic Process DNA Damage Response RNA Splicing SnRNA Catabolic Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Immune Response RRNA Catabolic Process Positive Regulation Of Cell Growth U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Positive Regulation Of Transcription By RNA Polymerase II Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Nuclear RNA decay	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		17 interacting genes: CEBPA DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 USP7 XRN1	21 interacting genes: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 ERG EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 HBS1L MTREX PALS2 SETX SUMO2 UBE2I ZDHHC17
Entrez ID		23517	5393
HPRD ID		13777	07315
Ensembl ID		ENSG00000039123	ENSG00000123737
Uniprot IDs		P42285 Q3MHC9	B4DXG8 Q06265
PDB IDs		6C90 6D6Q 6D6R 6IEG 6IEH 6RO1 7S7B 7S7C 7Z4Y 7Z4Z 7Z52	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process SnRNA 3'-end Processing RNA Catabolic Process SnRNA Processing Exoribonuclease Complex RRNA Metabolic Process SnRNA Metabolic Process RRNA Processing Nucleobase-containing Compound Catabolic Process 3'-5'-RNA Exonuclease Activity RNA 3'-end Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Negative Regulation Of Gene Expression Nucleic Acid Metabolic Process Sno(s)RNA Metabolic Process Nucleolus Macromolecule Catabolic Process MRNA 3'-UTR AU-rich Region Binding RNA Binding Nucleobase-containing Compound Metabolic Process RNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA Deamination Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process DNA Modification	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear RNA Surveillance RNA Surveillance MRNA Catabolic Process SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nucleobase-containing Compound Catabolic Process SnRNA Processing RRNA Catabolic Process MRNA Metabolic Process RRNA Processing RRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Macromolecule Catabolic Process 3'-5'-RNA Exonuclease Activity RNA Metabolic Process RNA Processing RNA Binding RNA 3'-end Processing Sno(s)RNA Metabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RRNA 3'-end Processing TRNA Decay DNA Deamination Catabolic Process Nucleolus Nucleobase-containing Compound Metabolic Process CUT Catabolic Process Nucleoplasm DNA Modification Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding Nucleus Negative Regulation Of Macromolecule Biosynthetic Process
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