MTREX and PALS2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		MTREX	PALS2
Description		Mtr4 exosome RNA helicase	protein associated with LIN7 2, MAGUK p55 family member
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing MRNA Processing RNA Catabolic Process DNA Damage Response RNA Splicing SnRNA Catabolic Process	Protein-containing Complex Assembly
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Nuclear RNA decay
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: CEBPA DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 USP7 XRN1	31 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 OGT PARN RPS20 SMARCA4 SNX9 THOP1 VPS26C WEE2-AS1
Entrez ID		23517	51678
HPRD ID		13777	09509
Ensembl ID		ENSG00000039123	ENSG00000105926
Uniprot IDs		P42285 Q3MHC9	B8ZZG1 Q9NZW5
PDB IDs		6C90 6D6Q 6D6R 6IEG 6IEH 6RO1 7S7B 7S7C 7Z4Y 7Z4Z 7Z52
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process SnRNA 3'-end Processing RNA Catabolic Process SnRNA Processing Exoribonuclease Complex RRNA Metabolic Process SnRNA Metabolic Process RRNA Processing Nucleobase-containing Compound Catabolic Process 3'-5'-RNA Exonuclease Activity RNA 3'-end Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Negative Regulation Of Gene Expression Nucleic Acid Metabolic Process Sno(s)RNA Metabolic Process Nucleolus Macromolecule Catabolic Process MRNA 3'-UTR AU-rich Region Binding RNA Binding Nucleobase-containing Compound Metabolic Process RNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA Deamination Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process DNA Modification	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process
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