SKIV2L2 and MPP6

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid)

		SKIV2L2	MPP6
Gene Name		superkiller viralicidic activity 2-like 2 (S. cerevisiae)	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Catalytic Step 2 Spliceosome	Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Protein Binding PDZ Domain Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA	Protein Complex Assembly
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPHOSPH6 MPP6 PBX2 SP1 UPF2 XRN1	28 interactors: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 NDN NFKB1 PARN RPS20 SKIV2L2 SMARCA4 SNX9 THOP1
Entrez ID		23517	51678
HPRD ID		13777	09509
Ensembl ID		ENSG00000039123	ENSG00000105926
Uniprot IDs		P42285 Q3MHC9	B8ZZG1 Q9NZW5
PDB IDs
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis NcRNA Metabolic Process Ribonucleoprotein Complex Biogenesis Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Metabolic Process RNA Metabolic Process Nuclear MRNA Surveillance Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Gene Expression DNA Deamination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Cellular Metabolic Process Histone MRNA Catabolic Process DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process Positive Regulation Of Growth Metabolic Process Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of Cell Growth Negative Regulation Of Nodal Signaling Pathway Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis RRNA Processing RRNA Metabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance NcRNA Metabolic Process RNA Surveillance RRNA Catabolic Process Cellular Macromolecule Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Maturation Of 5.8S RRNA Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Gene Expression RNA Metabolic Process DNA Deamination Catabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Growth Histone MRNA Catabolic Process Regulation Of Growth Intracellular MRNA Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-lipid Complex Assembly Histone MRNA Metabolic Process Membrane Organization Positive Regulation Of Cell Growth Cellular Process RNA Processing Cellular Metabolic Process Regulation Of Cholesterol Transport Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Interleukin-12 Biosynthetic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		accessed actg1 affymetrix b2m bafl bioinformatics broadly c12orf35 cbaciu de devastating dynlt1 edu filtering handle html ilkap lo pipeline qrt reasonable sals suite supplementary tardbp tm4 twelve uncc webpages	binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover
Tagcloud (Difference) ?		accessed actg1 affymetrix b2m bafl bioinformatics broadly c12orf35 cbaciu de devastating dynlt1 edu filtering handle html ilkap lo pipeline qrt reasonable sals suite supplementary tardbp tm4 twelve uncc webpages	binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover
Tagcloud (Intersection) ?