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SKIV2L2 and EXOSC6
Number of citations of the paper that reports this interaction (PMID
11719186
)
268
Data Source:
BioGRID
(two hybrid)
HPRD
(in vivo, two hybrid)
SKIV2L2
EXOSC6
Gene Name
superkiller viralicidic activity 2-like 2 (S. cerevisiae)
exosome component 6
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Catalytic Step 2 Spliceosome
Exosome (RNase Complex)
Nucleolus
Cytosol
Molecular Function
Helicase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
Exoribonuclease Activity
Poly(A) RNA Binding
Biological Process
MRNA Splicing, Via Spliceosome
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Isotype Switching
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
14 interactors:
DIS3
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
MPHOSPH6
MPP6
PBX2
SP1
UPF2
XRN1
35 interactors:
C1QBP
CHPF
DCP1B
DIS3
DNAJC30
EIF3I
ESRRA
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC7
EXOSC8
EXOSC9
GSE1
LSM1
LSM7
LSM8
MAN2C1
MIF4GD
MOCS3
MPP6
MRPL4
MRPS18B
NDUFA13
NUDT21
PSMB1
RAB3GAP2
SKIV2L2
SRSF3
TUFM
UPF2
XRN1
ZFP36
Entrez ID
23517
118460
HPRD ID
13777
12107
Ensembl ID
ENSG00000039123
ENSG00000223496
Uniprot IDs
P42285
Q3MHC9
Q5RKV6
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
Ribosome Biogenesis
NcRNA Metabolic Process
Ribonucleoprotein Complex Biogenesis
Aromatic Compound Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
MRNA Metabolic Process
RNA Metabolic Process
Nuclear MRNA Surveillance
Cellular Macromolecule Catabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis
RRNA Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Maturation Of 5.8S RRNA
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Catabolic Process
Gene Expression
DNA Deamination
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Cellular Metabolic Process
Histone MRNA Catabolic Process
DNA Modification
Positive Regulation Of Cell Growth
Histone MRNA Metabolic Process
Positive Regulation Of Growth
Metabolic Process
Sequestering Of Nodal From Receptor Via Nodal Binding
Regulation Of Cell Growth
Negative Regulation Of Nodal Signaling Pathway
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Metabolic Process
MRNA Catabolic Process
RNA Catabolic Process
RRNA Metabolic Process
Aromatic Compound Catabolic Process
Ribosome Biogenesis
RRNA Processing
Ribonucleoprotein Complex Biogenesis
Gene Expression
Cellular Macromolecule Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
NcRNA Metabolic Process
Nuclear MRNA Surveillance
RNA Metabolic Process
RNA Surveillance
RRNA Catabolic Process
Maturation Of 5.8S RRNA
RNA Phosphodiester Bond Hydrolysis
Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Catabolic Process
Nucleobase-containing Compound Metabolic Process
Histone MRNA Catabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Processing
Cellular Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Histone MRNA Metabolic Process
MRNA Processing
RNA Splicing
Metabolic Process
RNA 3'-end Processing
RNA Splicing, Via Transesterification Reactions
RNA Localization
DNA Deamination
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Intracellular MRNA Localization
Mitochondrial Translational Elongation
MRNA 3'-end Processing
Mitochondrion Organization
Mitochondrial Translation
MRNA Splicing, Via Spliceosome
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Tagcloud
?
accessed
actg1
affymetrix
b2m
bafl
bioinformatics
broadly
c12orf35
cbaciu
de
devastating
dynlt1
edu
filtering
handle
html
ilkap
lo
pipeline
qrt
reasonable
sals
suite
supplementary
tardbp
tm4
twelve
uncc
webpages
Tagcloud (Difference)
?
accessed
actg1
affymetrix
b2m
bafl
bioinformatics
broadly
c12orf35
cbaciu
de
devastating
dynlt1
edu
filtering
handle
html
ilkap
lo
pipeline
qrt
reasonable
sals
suite
supplementary
tardbp
tm4
twelve
uncc
webpages
Tagcloud (Intersection)
?