SKIV2L2 and EXOSC7

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
HPRD (in vivo)

		SKIV2L2	EXOSC7
Gene Name		superkiller viralicidic activity 2-like 2 (S. cerevisiae)	exosome component 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Catalytic Step 2 Spliceosome	Exosome (RNase Complex) Nucleus Nucleolus Cytosol
	Molecular Function	Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing RNA Catabolic Process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPHOSPH6 MPP6 PBX2 SP1 UPF2 XRN1	14 interactors: APP DIS3 DXO EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 IP6K1 MPP6 SKIV2L2
Entrez ID		23517	23016
HPRD ID		13777	09401
Ensembl ID		ENSG00000039123	ENSG00000075914
Uniprot IDs		P42285 Q3MHC9	B2RDZ9 Q15024
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis NcRNA Metabolic Process Ribonucleoprotein Complex Biogenesis Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Metabolic Process RNA Metabolic Process Nuclear MRNA Surveillance Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Gene Expression DNA Deamination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Cellular Metabolic Process Histone MRNA Catabolic Process DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process Positive Regulation Of Growth Metabolic Process Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of Cell Growth Negative Regulation Of Nodal Signaling Pathway Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process	RRNA Processing RRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Deamination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Histone MRNA Catabolic Process Intracellular MRNA Localization DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process RNA Processing Positive Regulation Of Growth Regulation Of Growth Metabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Synaptic Growth At Neuromuscular Junction Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA 3'-end Processing
Tagcloud ?		accessed actg1 affymetrix b2m bafl bioinformatics broadly c12orf35 cbaciu de devastating dynlt1 edu filtering handle html ilkap lo pipeline qrt reasonable sals suite supplementary tardbp tm4 twelve uncc webpages
Tagcloud (Difference) ?		accessed actg1 affymetrix b2m bafl bioinformatics broadly c12orf35 cbaciu de devastating dynlt1 edu filtering handle html ilkap lo pipeline qrt reasonable sals suite supplementary tardbp tm4 twelve uncc webpages
Tagcloud (Intersection) ?