DIS3 and EXOSC7

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
HPRD (in vivo)

		DIS3	EXOSC7
Gene Name		DIS3 exosome endoribonuclease and 3-5 exoribonuclease	exosome component 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane	Exosome (RNase Complex) Nucleus Nucleolus Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression RRNA Catabolic Process Positive Regulation Of GTPase Activity Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing RNA Catabolic Process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPP6 NTMT1 SKIV2L2 ZBTB17	14 interactors: APP DIS3 DXO EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 IP6K1 MPP6 SKIV2L2
Entrez ID		22894	23016
HPRD ID		06338	09401
Ensembl ID		ENSG00000083520	ENSG00000075914
Uniprot IDs		G3V1J5 Q9Y2L1	B2RDZ9 Q15024
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Catabolic Process Maturation Of 5.8S RRNA MRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis DNA Deamination RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process CUT Catabolic Process Histone MRNA Catabolic Process DNA Modification Intracellular MRNA Localization Positive Regulation Of Cell Growth Cellular Metabolic Process Histone MRNA Metabolic Process Positive Regulation Of Growth N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-alanine Trimethylation Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Metabolic Process	RRNA Processing RRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Deamination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Histone MRNA Catabolic Process Intracellular MRNA Localization DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process RNA Processing Positive Regulation Of Growth Regulation Of Growth Metabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Synaptic Growth At Neuromuscular Junction Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA 3'-end Processing
Tagcloud ?		braf copy decisions deletions determining discovered emphasize fam46c heterogeneity heterozygosity homozygous kras massively modeling mutated myeloma nonhyperdiploid nonmutated nras paired parallel partial particularly predicts promotion putative subclonal subclones tp53
Tagcloud (Difference) ?		braf copy decisions deletions determining discovered emphasize fam46c heterogeneity heterozygosity homozygous kras massively modeling mutated myeloma nonhyperdiploid nonmutated nras paired parallel partial particularly predicts promotion putative subclonal subclones tp53
Tagcloud (Intersection) ?