DIS3 and MTREX

Number of citations of the paper that reports this interaction (PubMedID 11719186)
0

Data Source:
HPRD (in vivo)

		DIS3	MTREX
Description		DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease	Mtr4 exosome RNA helicase
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity RNA Nuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Hydrolase Activity	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Nuclear MRNA Surveillance Of MRNA 3'-end Processing CUT Catabolic Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing MRNA Processing RNA Catabolic Process DNA Damage Response RNA Splicing SnRNA Catabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Nuclear RNA decay
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)
Interacting Genes		13 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 RNF10 ZBTB17	17 interacting genes: CEBPA DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 USP7 XRN1
Entrez ID		22894	23517
HPRD ID		06338	13777
Ensembl ID		ENSG00000083520	ENSG00000039123
Uniprot IDs		G3V1J5 Q9Y2L1	P42285 Q3MHC9
PDB IDs		6D6Q 6D6R 6H25	6C90 6D6Q 6D6R 6IEG 6IEH 6RO1 7S7B 7S7C 7Z4Y 7Z4Z 7Z52
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Processing RNA 3'-end Processing RRNA Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance RNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear-transcribed MRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process RRNA Processing Poly(A)-dependent SnoRNA 3'-end Processing MRNA Catabolic Process RRNA Metabolic Process RRNA 3'-end Processing 3'-5'-RNA Exonuclease Activity TRNA Decay Nucleobase-containing Compound Catabolic Process Sno(s)RNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA Processing Nucleolus MRNA 3'-UTR AU-rich Region Binding Catabolic Process DNA Deamination RNA Metabolic Process RNA Binding TRNA Metabolic Process Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA DNA Modification Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process SnRNA Catabolic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process SnRNA 3'-end Processing RNA Catabolic Process SnRNA Processing Exoribonuclease Complex RRNA Metabolic Process SnRNA Metabolic Process RRNA Processing Nucleobase-containing Compound Catabolic Process 3'-5'-RNA Exonuclease Activity RNA 3'-end Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Negative Regulation Of Gene Expression Nucleic Acid Metabolic Process Sno(s)RNA Metabolic Process Nucleolus Macromolecule Catabolic Process MRNA 3'-UTR AU-rich Region Binding RNA Binding Nucleobase-containing Compound Metabolic Process RNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA Deamination Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process DNA Modification
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