DIS3 and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical, two hybrid)
HPRD (in vivo)

		DIS3	EXOSC8
Description		DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease	exosome component 8
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity RNA Nuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Hydrolase Activity	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Nuclear MRNA Surveillance Of MRNA 3'-end Processing CUT Catabolic Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)
Interacting Genes		13 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 RNF10 ZBTB17	112 interacting genes: AEN ANKHD1 ATF2 C22orf39 CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36
Entrez ID		22894	11340
HPRD ID		06338	09351
Ensembl ID		ENSG00000083520	ENSG00000120699
Uniprot IDs		G3V1J5 Q9Y2L1	Q96B26
PDB IDs		6D6Q 6D6R 6H25	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Processing RNA 3'-end Processing RRNA Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance RNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear-transcribed MRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process RRNA Processing Poly(A)-dependent SnoRNA 3'-end Processing MRNA Catabolic Process RRNA Metabolic Process RRNA 3'-end Processing 3'-5'-RNA Exonuclease Activity TRNA Decay Nucleobase-containing Compound Catabolic Process Sno(s)RNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA Processing Nucleolus MRNA 3'-UTR AU-rich Region Binding Catabolic Process DNA Deamination RNA Metabolic Process RNA Binding TRNA Metabolic Process Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA DNA Modification Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process SnRNA Catabolic Process	RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding
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