DIS3 and EXOSC5

Number of citations of the paper that reports this interaction (PubMedID 20531386)
64

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DIS3	EXOSC5
Description		DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease	exosome component 5
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity RNA Nuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Hydrolase Activity	3'-5'-RNA Exonuclease Activity DNA Binding RNA Binding RNA Exonuclease Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Nuclear MRNA Surveillance Of MRNA 3'-end Processing CUT Catabolic Process	RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)	Appendicular lean mass ( 33097823)
Interacting Genes		13 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 RNF10 ZBTB17	82 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 CEP55 CPSF7 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 YTHDF3 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792
Entrez ID		22894	56915
HPRD ID		06338	16222
Ensembl ID		ENSG00000083520	ENSG00000077348
Uniprot IDs		G3V1J5 Q9Y2L1	Q9NQT4
PDB IDs		6D6Q 6D6R 6H25	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Processing RNA 3'-end Processing RRNA Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance RNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear-transcribed MRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process RRNA Processing Poly(A)-dependent SnoRNA 3'-end Processing MRNA Catabolic Process RRNA Metabolic Process RRNA 3'-end Processing 3'-5'-RNA Exonuclease Activity TRNA Decay Nucleobase-containing Compound Catabolic Process Sno(s)RNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA Processing Nucleolus MRNA 3'-UTR AU-rich Region Binding Catabolic Process DNA Deamination RNA Metabolic Process RNA Binding TRNA Metabolic Process Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA DNA Modification Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process SnRNA Catabolic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay Nuclear MRNA Surveillance Nuclear RNA Surveillance RNA Surveillance RRNA Processing SnRNA Metabolic Process RRNA Metabolic Process RNA 3'-end Processing RNA Processing SnRNA 3'-end Processing CUT Catabolic Process RNA Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Processing MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process RNA Metabolic Process Sno(s)RNA Metabolic Process Exoribonuclease Complex TRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Structural Constituent Of Skin Epidermis Cytosol Intermediate Filament Organization Nucleic Acid Metabolic Process RNA Binding Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination
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