EEF1E1 and CALCOCO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		EEF1E1	CALCOCO2
Description		eukaryotic translation elongation factor 1 epsilon 1	calcium binding and coiled-coil domain 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Translation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway	Autophagy Viral Process Response To Type II Interferon Xenophagy Positive Regulation Of Autophagosome Maturation
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Refractive error ( 32231278) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronotype ( 30696823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		7 interacting genes: ATM ATR CALCOCO2 CDC42 CEBPA FNDC3B NAT9	182 interacting genes: ABLIM1 ADSL AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 ATOSB AXIN1 BAHD1 BCL6B CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 ENTREP1 EXOSC5 FAM107A FAM161A FAM168A FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FMR1 FNDC11 FOXD4L3 FUBP3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPA1 HNRNPK HNRNPLL HOXB5 HOXB9 IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBRG4 TCL1A TEKT3 TENT2 TLE5 TNFAIP3 TP53RK TRAF2 TRAF4 TSC1 TSGA10IP TTC23L UBAC2 UBC ULK1 USP2 VARS1 VPS72 WWP2 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80
Entrez ID		9521	10241
HPRD ID		10931	06846
Ensembl ID		ENSG00000124802	ENSG00000136436
Uniprot IDs		O43324	Q13137
PDB IDs		2UZ8 4BL7 4BVX 4BVY 5BMU 5Y6L	2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L 7EAA
Enriched GO Terms of Interacting Partners?		Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Histone H2AXS139 Kinase Activity DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Regulation Of Cellular Response To Heat Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Organelle Organization Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Site Of Double-strand Break Cellular Response To Gamma Radiation Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Macrophage Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Tubulin N-terminal-methionine Acetyltransferase Activity Regulation Of Cell Cycle Regulation Of Protein-containing Complex Assembly Regulation Of DNA Biosynthetic Process Positive Regulation Of Cellular Component Organization Protein Localization To Chromosome Regulation Of G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Positive Regulation Of Macroautophagy DNA Damage Checkpoint Signaling ATR-ATRIP Complex PML Body Response To Type II Interferon GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Positive Regulation Of Cellular Component Biogenesis Regulation Of Mitotic Nuclear Division	Protein Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding MRNA Processing MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Cytoplasm RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process RNA Metabolic Process Metal Ion Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nutrient Levels RNA Processing Macromolecule Metabolic Process Response To Starvation Autophagy Of Mitochondrion Spliceosomal Complex Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of MRNA Metabolic Process Autophagosome Autophagosome Membrane Negative Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission SnRNP Binding Mitophagy Negative Regulation Of Nucleobase-containing Compound Metabolic Process Phosphatidylethanolamine Binding Negative Regulation Of Gene Expression Cytoplasmic Stress Granule
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