PLEKHA5 and EVPL

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PLEKHA5	EVPL
Description		pleckstrin homology domain containing A5	envoplakin
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Structural Molecule Activity Cadherin Binding
	Biological Process	Reproductive System Development	Regulation Of Antibacterial Peptide Production Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Synthesis of PIPs at the plasma membrane	Formation of the cornified envelope
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)	Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		54477	2125
HPRD ID		09684	03352
Ensembl ID		ENSG00000052126	ENSG00000167880
Uniprot IDs		A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0	B7ZLH8 K7EKI0 Q92817
PDB IDs		2DKP	4QMD
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly	Cornified Envelope Peptide Cross-linking Keratinization Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Epidermal Cell Differentiation Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Epidermis Development Epithelial Cell Differentiation Keratin Filament Cytoskeleton Organization Protein Modification Process Structural Molecule Activity Wound Healing Supramolecular Fiber Organization Cytosol Extracellular Exosome Protein Heterotetramerization Tissue Development Protein Heterooligomerization Desmosome Positive Regulation Of Epidermis Development Response To Wounding Endopeptidase Inhibitor Activity Cytoplasm Protein Metabolic Process Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Polymerization Humoral Immune Response Antibacterial Humoral Response Regulation Of Epidermis Development Developmental Process Scaffold Protein Binding Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Copulation Organelle Organization Protein Tetramerization Peptidase Inhibitor Complex Peptidase Inhibitor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cellular Developmental Process Extracellular Space Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Keratinocyte Migration Cardiac Muscle Cell-cardiac Muscle Cell Adhesion
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