PLEKHA5 and LAMB2

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PLEKHA5	LAMB2
Gene Name		pleckstrin homology domain containing, family A member 5	laminin, beta 2 (laminin S)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Extracellular Region Basement Membrane Basal Lamina Laminin-3 Complex Extracellular Matrix Laminin-11 Complex Synapse Extracellular Vesicular Exosome
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Integrin Binding Structural Molecule Activity
	Biological Process	Biological_process Reproductive System Development	Cell Adhesion Axon Guidance Neuromuscular Junction Development Visual Perception Astrocyte Development Schwann Cell Development Extracellular Matrix Organization Axon Extension Involved In Regeneration Retina Development In Camera-type Eye Metanephric Glomerular Visceral Epithelial Cell Development Metanephric Glomerular Basement Membrane Development
Pathways			Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 UPF1 WASH2P YWHAG	8 interactors: ATXN7 KPNA2 ORC5 PIK3R2 PLEKHA5 RBL1 STAT3 ZNF512B
Entrez ID		54477	3913
HPRD ID		09684	01034
Ensembl ID		ENSG00000052126	ENSG00000172037
Uniprot IDs		Q9HAU0	P55268
PDB IDs		2DKP
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Hemidesmosome Assembly Glomerular Visceral Epithelial Cell Differentiation Regulation Of Protein Complex Disassembly Cellular Localization Regulation Of Cellular Component Organization Movement Of Cell Or Subcellular Component Cellular Process Retina Development In Camera-type Eye Organelle Organization Generation Of Neurons Cell Differentiation Involved In Kidney Development Neuron Differentiation Cytoskeleton Organization Regulation Of Actin Filament Polymerization Microtubule-based Process Neurogenesis Metanephric Glomerular Basement Membrane Development Axon Extension Involved In Regeneration Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell-substrate Junction Assembly Actin Filament Capping Membrane Organization Regulation Of Cytoskeleton Organization Glomerulus Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Regulation Of Organelle Organization Metanephric Glomerular Visceral Epithelial Cell Development Response To Axon Injury Protein Localization Neuron Development Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Polymerization Sensory Organ Development Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Centriole-centriole Cohesion Response To Insulin Establishment Of Localization In Cell Microtubule-based Movement Intracellular Transport Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport	Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Viral Process Protein Import Into Nucleus Nuclear Import Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Import Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Protein Localization To Nucleus Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glucose Homeostasis Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Glycolytic Process Cellular Macromolecule Biosynthetic Process Radial Glial Cell Differentiation Macromolecule Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Lipid Metabolic Process Transcription, DNA-templated Cellular Response To Peptide Hormone Stimulus Interleukin-6-mediated Signaling Pathway Cellular Response To Peptide RNA Biosynthetic Process Establishment Of Protein Localization To Organelle Response To Organic Substance Regulation Of Transcription, DNA-templated Histone Deubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process NLS-bearing Protein Import Into Nucleus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation
Tagcloud ?		a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul
Tagcloud (Difference) ?		a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul
Tagcloud (Intersection) ?