PLEKHA5 and MAX

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PLEKHA5	MAX
Gene Name		pleckstrin homology domain containing, family A member 5	MYC associated factor X
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm PML Body Dendrite MLL1 Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Protein Complex Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Biological_process Reproductive System Development	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cellular Response To Starvation Negative Regulation Of Gene Expression Response To Insulin Response To Axon Injury Neuron Apoptotic Process Retina Development In Camera-type Eye Cellular Response To Peptide Hormone Stimulus
Pathways			G1/S Transition Cyclin E associated events during G1/S transition S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Anthropometric traits ( 19260139) Blood trace element (Zn levels) ( 23720494) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517)
Protein-Protein Interactions		30 interactors: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 UPF1 WASH2P YWHAG	43 interactors: BANP CASP5 CASP7 CLIP2 COPS5 CSNK2A1 CUX1 EP300 EPAS1 FTH1 FUS GABBR1 HIF1A MAD1L1 MAPK14 MGA MNT MSH2 MXD1 MXD3 MXD4 MXI1 MYC MYCL MYCLP1 MYCN PLEKHA5 PLEKHF2 PLIN3 RPL34 RPL35 SMAD3 SMAD4 SNIP1 SPAG9 TAF1 TCF3 TEAD1 TRRAP TUBA1A TXLNG UNC45A ZBTB17
Entrez ID		54477	4149
HPRD ID		09684	01113
Ensembl ID		ENSG00000052126	ENSG00000125952
Uniprot IDs		Q9HAU0	P61244 Q8TAX8
PDB IDs		2DKP	1AN2 1HLO 1NKP 1NLW 1R05
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Hemidesmosome Assembly Glomerular Visceral Epithelial Cell Differentiation Regulation Of Protein Complex Disassembly Cellular Localization Regulation Of Cellular Component Organization Movement Of Cell Or Subcellular Component Cellular Process Retina Development In Camera-type Eye Organelle Organization Generation Of Neurons Cell Differentiation Involved In Kidney Development Neuron Differentiation Cytoskeleton Organization Regulation Of Actin Filament Polymerization Microtubule-based Process Neurogenesis Metanephric Glomerular Basement Membrane Development Axon Extension Involved In Regeneration Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell-substrate Junction Assembly Actin Filament Capping Membrane Organization Regulation Of Cytoskeleton Organization Glomerulus Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Regulation Of Organelle Organization Metanephric Glomerular Visceral Epithelial Cell Development Response To Axon Injury Protein Localization Neuron Development Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Polymerization Sensory Organ Development Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Centriole-centriole Cohesion Response To Insulin Establishment Of Localization In Cell Microtubule-based Movement Intracellular Transport Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport	RNA Biosynthetic Process RNA Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Tube Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of Cell Division Multicellular Organismal Development Negative Regulation Of Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Embryo Development Positive Regulation Of Cell Development Regulation Of Cellular Process Cellular Metabolic Process
Tagcloud ?		a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul	aminoiminomethyl behaves competitive dichloro dimethylquinolin displaced giving henyl int ips lf m1 muscarinic nonpeptide oxymethyl pa2 phenylcarbonyl phosphoinositosides piperazin plot pyrrolidine rbonyl saturation schild shifted slope sulphonyl umbilical unity yl
Tagcloud (Difference) ?		a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul	aminoiminomethyl behaves competitive dichloro dimethylquinolin displaced giving henyl int ips lf m1 muscarinic nonpeptide oxymethyl pa2 phenylcarbonyl phosphoinositosides piperazin plot pyrrolidine rbonyl saturation schild shifted slope sulphonyl umbilical unity yl
Tagcloud (Intersection) ?