PLEKHA5 and BLOC1S6

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PLEKHA5	BLOC1S6
Gene Name		pleckstrin homology domain containing, family A member 5	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Nucleoplasm Cytoplasm Endosome Cytosol Extrinsic Component Of Membrane Transport Vesicle BLOC-1 Complex SNARE Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding
	Biological Process	Biological_process Reproductive System Development	Post-Golgi Vesicle-mediated Transport Blood Coagulation Anterograde Axon Cargo Transport Synaptic Vesicle Docking Melanocyte Differentiation Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Endosome To Melanosome Transport Anterograde Synaptic Vesicle Transport Positive Regulation Of Pigment Cell Differentiation Membrane Organization Membrane Fusion
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 UPF1 WASH2P YWHAG	38 interactors: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 CCDC136 CCDC22 CCDC53 CCHCR1 CDK5R1 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 KRT13 LURAP1 MED21 NDC80 NDN NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 SKA1 SLC4A1 SMN2 SNAPIN STX11 STX12 SYCE3 TPM3 WDYHV1
Entrez ID		54477	26258
HPRD ID		09684	16055
Ensembl ID		ENSG00000052126	ENSG00000104164
Uniprot IDs		Q9HAU0	B3KY40 Q9UL45
PDB IDs		2DKP
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Hemidesmosome Assembly Glomerular Visceral Epithelial Cell Differentiation Regulation Of Protein Complex Disassembly Cellular Localization Regulation Of Cellular Component Organization Movement Of Cell Or Subcellular Component Cellular Process Retina Development In Camera-type Eye Organelle Organization Generation Of Neurons Cell Differentiation Involved In Kidney Development Neuron Differentiation Cytoskeleton Organization Regulation Of Actin Filament Polymerization Microtubule-based Process Neurogenesis Metanephric Glomerular Basement Membrane Development Axon Extension Involved In Regeneration Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell-substrate Junction Assembly Actin Filament Capping Membrane Organization Regulation Of Cytoskeleton Organization Glomerulus Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Regulation Of Organelle Organization Metanephric Glomerular Visceral Epithelial Cell Development Response To Axon Injury Protein Localization Neuron Development Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Polymerization Sensory Organ Development Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Centriole-centriole Cohesion Response To Insulin Establishment Of Localization In Cell Microtubule-based Movement Intracellular Transport Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport	Anterograde Synaptic Vesicle Transport Establishment Of Localization In Cell Axon Cargo Transport Melanosome Organization Pigment Granule Organization Organelle Organization Cellular Pigmentation Anterograde Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Localization Organelle Localization Synaptic Vesicle Transport Movement Of Cell Or Subcellular Component Establishment Of Vesicle Localization Intracellular Transport Pigmentation Vesicle Organization Establishment Of Organelle Localization Vesicle Localization Membrane Organization Neuron Development Microtubule-based Process Neuron Projection Development Platelet Dense Granule Organization Microtubule-based Movement Cytoskeleton Organization Neuron Differentiation Cell Projection Organization Vesicle-mediated Transport Protein Localization Protein Transport Establishment Of Protein Localization Cell Development Post-Golgi Vesicle-mediated Transport Generation Of Neurons Cellular Protein Localization Neurogenesis Neuron Recognition Secretory Granule Organization Transport Endomembrane System Organization Golgi Vesicle Transport Vesicle Fusion Nervous System Development Mitotic Nuclear Division Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Exocytosis Organelle Fusion
Tagcloud ?		a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul
Tagcloud (Difference) ?		a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul
Tagcloud (Intersection) ?