PLEKHA5 and CEP250

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PLEKHA5	CEP250
Gene Name		pleckstrin homology domain containing, family A member 5	centrosomal protein 250kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Centrosome Centriole Microtubule Organizing Center Cytosol Cilium Spindle Pole Centrosome Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Biological_process Reproductive System Development	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Protein Localization Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Height ( 18391951) Ulcerative colitis ( 23128233)
Protein-Protein Interactions		30 interactors: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 UPF1 WASH2P YWHAG	6 interactors: APP ATF7IP KAT2B NEK2 PLEKHA5 YWHAG
Entrez ID		54477	11190
HPRD ID		09684	09877
Ensembl ID		ENSG00000052126	ENSG00000126001
Uniprot IDs		Q9HAU0	Q9BV73
PDB IDs		2DKP
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Hemidesmosome Assembly Glomerular Visceral Epithelial Cell Differentiation Regulation Of Protein Complex Disassembly Cellular Localization Regulation Of Cellular Component Organization Movement Of Cell Or Subcellular Component Cellular Process Retina Development In Camera-type Eye Organelle Organization Generation Of Neurons Cell Differentiation Involved In Kidney Development Neuron Differentiation Cytoskeleton Organization Regulation Of Actin Filament Polymerization Microtubule-based Process Neurogenesis Metanephric Glomerular Basement Membrane Development Axon Extension Involved In Regeneration Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell-substrate Junction Assembly Actin Filament Capping Membrane Organization Regulation Of Cytoskeleton Organization Glomerulus Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Regulation Of Organelle Organization Metanephric Glomerular Visceral Epithelial Cell Development Response To Axon Injury Protein Localization Neuron Development Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Polymerization Sensory Organ Development Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Centriole-centriole Cohesion Response To Insulin Establishment Of Localization In Cell Microtubule-based Movement Intracellular Transport Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport	Negative Regulation Of Centriole-centriole Cohesion G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Collateral Sprouting In Absence Of Injury Regulation Of Centriole-centriole Cohesion N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Cellular Response To Insulin Stimulus Regulation Of Mitotic Centrosome Separation Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Chromosome Organization Cell Cycle Process Axon Choice Point Recognition Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Regulation Of Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Response To Insulin Neuron Remodeling Negative Regulation Of Transferase Activity Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Glycosylation Negative Regulation Of Protein Phosphorylation Cellular Response To Peptide Regulation Of Phosphorylation N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated Cell Cycle Organelle Organization Centrosome Separation Negative Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process
Tagcloud ?		a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul
Tagcloud (Difference) ?		a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul
Tagcloud (Intersection) ?