PLEKHA5 and EXTL3

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PLEKHA5	EXTL3
Description		pleckstrin homology domain containing A5	exostosin like glycosyltransferase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Magnesium Ion Binding Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity Protein Binding Acetylglucosaminyltransferase Activity Protein-hormone Receptor Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Reproductive System Development	Protein Glycosylation Positive Regulation Of Keratinocyte Proliferation Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Cell Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Detection Of Glucose
Pathways		Synthesis of PIPs at the plasma membrane	HS-GAG biosynthesis XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)	Height ( 25429064) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Moderate-to-late spontaneous preterm birth ( 31194736)
Interacting Genes		30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	4 interacting genes: ATXN1 DSCR9 LCOR PLEKHA5
Entrez ID		54477	2137
HPRD ID		09684	09306
Ensembl ID		ENSG00000052126	ENSG00000012232
Uniprot IDs		A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0	A0A384NPY9 O43909
PDB IDs		2DKP	7AU2 7AUA 8OG1 8OG4
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly
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