EVPL and SPRR2A

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
HPRD (in vivo)

		EVPL	SPRR2A
Description		envoplakin	small proline rich protein 2A
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction	Cornified Envelope Extracellular Region Cytoplasm Cytosol Transport Vesicle Secretory Granule Cytoplasmic Vesicle
	Molecular Function	Structural Molecule Activity Cadherin Binding	Protein Binding Lipid Binding
	Biological Process	Regulation Of Antibacterial Peptide Production Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization	Antibacterial Humoral Response Defense Response To Bacterium Host-mediated Modulation Of Intestinal Microbiota Composition Defense Response To Gram-positive Bacterium
Pathways		Formation of the cornified envelope	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3	10 interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 YES1
Entrez ID		2125	6700
HPRD ID		03352	01649
Ensembl ID		ENSG00000167880	ENSG00000241794
Uniprot IDs		B7ZLH8 K7EKI0 Q92817	P35326
PDB IDs		4QMD
Enriched GO Terms of Interacting Partners?		Cornified Envelope Peptide Cross-linking Keratinization Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Epidermal Cell Differentiation Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Epidermis Development Epithelial Cell Differentiation Keratin Filament Cytoskeleton Organization Protein Modification Process Structural Molecule Activity Wound Healing Supramolecular Fiber Organization Cytosol Extracellular Exosome Protein Heterotetramerization Tissue Development Protein Heterooligomerization Desmosome Positive Regulation Of Epidermis Development Response To Wounding Endopeptidase Inhibitor Activity Cytoplasm Protein Metabolic Process Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Polymerization Humoral Immune Response Antibacterial Humoral Response Regulation Of Epidermis Development Developmental Process Scaffold Protein Binding Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Copulation Organelle Organization Protein Tetramerization Peptidase Inhibitor Complex Peptidase Inhibitor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cellular Developmental Process Extracellular Space Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Keratinocyte Migration Cardiac Muscle Cell-cardiac Muscle Cell Adhesion	Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Cytosol Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Kinase Activity Regulation Of Immune Response Response To Transforming Growth Factor Beta Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Motility Actin Filament Immune Response-regulating Cell Surface Receptor Signaling Pathway Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Immune Response-activating Signaling Pathway Proline-rich Region Binding Regulation Of Actin Filament-based Process Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Cellular Response To Oxygen-containing Compound Response To Reactive Oxygen Species Ephrin Receptor Binding Cell Migration Cortical Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Dendritic Spine Organization Positive Regulation Of Cytoskeleton Organization Protein Modification Process Regulation Of Cytoskeleton Organization Negative Regulation Of Immune Response Regulation Of Biological Quality Intracellular Protein Localization SH2 Domain Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Organization Postsynapse Organization Postsynapse Leukocyte Migration Positive Regulation Of Locomotion
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