DXO and FLOT2

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
HPRD (two hybrid)

		DXO	FLOT2
Description		decapping exoribonuclease	flotillin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Uropod Acrosomal Membrane Endosome Plasma Membrane Caveola Adherens Junction Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Endocytic Vesicle Cortical Actin Cytoskeleton Cytoplasmic Vesicle Vesicle Dendrite Cytoplasm Cell-cell Contact Zone Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding MRNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity MRNA 5'-diphosphatase Activity Metal Ion Binding RNA NAD+-cap (NAD+-forming) Hydrolase Activity	Protease Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Destabilization Nuclear MRNA Surveillance Nucleic Acid Metabolic Process NAD-cap Decapping	Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Plasma Membrane Raft Regulation Of Myoblast Differentiation Protein Stabilization Protein Localization To Plasma Membrane Anterograde Dendritic Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Establishment Of T Cell Polarity
Pathways		Nuclear RNA decay	RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RND3 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Declining hemoglobin trajectory in blood donors ( 33491795) Mean corpuscular hemoglobin ( 29403010) Red blood cell count ( 27863252)
Interacting Genes		8 interacting genes: EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2	12 interacting genes: ANXA1 APP CAV1 CAV2 DXO FLOT1 FYN HGS MAGEB4 NMNAT1 SPATA24 UBC
Entrez ID		1797	2319
HPRD ID		16186	00580
Ensembl ID		ENSG00000204348	ENSG00000132589
Uniprot IDs		A0A024RCW8 A0A1U9X7N5 F8WC68 O77932	J3QLD9 Q14254 Q6FG43 Q9BTI6
PDB IDs			9BQ2
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance MRNA Catabolic Process Histone MRNA Catabolic Process RNA Catabolic Process Histone MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Nuclear RNA Surveillance Negative Regulation Of Gene Expression RNA Surveillance Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Metabolic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Nuclear Exosome (RNase Complex) RRNA Catabolic Process RRNA Metabolic Process Exosome (RNase Complex) Negative Regulation Of Metabolic Process MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Exonuclease Activity Nucleolus SnRNA Metabolic Process RRNA Processing Macromolecule Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Regulation Of Gene Expression RNA 3'-end Processing Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process RRNA 3'-end Processing 5'-3' Exonuclease Activity TRNA Decay RNA Metabolic Process Regulation Of Telomere Maintenance Nuclease Activity RNA Binding Regulation Of Macromolecule Metabolic Process Sno(s)RNA Metabolic Process	Caveola Assembly Plasma Membrane Raft Assembly Membrane Raft Assembly Plasma Membrane Raft Organization Membrane Raft Caveolar Macromolecular Signaling Complex Membrane Raft Organization Growth Factor Receptor Binding Endosome Early Endosome Membrane Endocytosis Membrane Assembly Peptidase Activator Activity Caveola Regulation Of Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Receptor-mediated Endocytosis Of Virus By Host Cell Cellular Response To Growth Factor Stimulus Regulation Of Dendritic Spine Maintenance Import Into Cell Endocytosis Involved In Viral Entry Into Host Cell Response To Growth Factor Early Endosome Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of Neurotransmitter Uptake Regulation Of Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Signaling Receptor Binding Positive Regulation Of Cell Activation G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Acrosomal Membrane Focal Adhesion Positive Regulation Of Transport Cytoplasmic Vesicle Regulation Of Extrinsic Apoptotic Signaling Pathway Ephrin Receptor Binding Negative Regulation Of Receptor Signaling Pathway Via STAT Receptor-mediated Endocytosis Basement Membrane Organization Negative Regulation Of Macromolecule Biosynthetic Process Plasma Membrane Raft Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Negative Regulation Of Biosynthetic Process Endothelial Cell Proliferation Regulation Of Cell-cell Adhesion
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