DXO and EXOSC7

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DXO	EXOSC7
Description		decapping exoribonuclease	exosome component 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding MRNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity MRNA 5'-diphosphatase Activity Metal Ion Binding RNA NAD+-cap (NAD+-forming) Hydrolase Activity	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Destabilization Nuclear MRNA Surveillance Nucleic Acid Metabolic Process NAD-cap Decapping	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		Nuclear RNA decay	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Acne (severe) ( 24927181) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862)
Interacting Genes		8 interacting genes: EXOSC10 EXOSC4 EXOSC7 FLOT2 PRMT6 UPF1 XRN1 XRN2	46 interacting genes: ALG13 APP C1orf35 CCDC59 DIS3 DMRTB1 DPYSL2 DXO EHMT2 EIF4ENIF1 ESRRG ESS2 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 HOOK1 IP6K1 KIF24 KRT31 LARP4 MIF MTREX PALS2 PRC1 PRPF6 PRRC2B PTEN RALYL RBM22 RBM7 RBPMS RPA2 RPL21 SNRNP48 SNW1 SUPT5H TFIP11 THOC1 UBE2K UNKL VIM
Entrez ID		1797	23016
HPRD ID		16186	09401
Ensembl ID		ENSG00000204348	ENSG00000075914
Uniprot IDs		A0A024RCW8 A0A1U9X7N5 F8WC68 O77932	B2RDZ9 Q15024
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance MRNA Catabolic Process Histone MRNA Catabolic Process RNA Catabolic Process Histone MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Nuclear RNA Surveillance Negative Regulation Of Gene Expression RNA Surveillance Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Metabolic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Nuclear Exosome (RNase Complex) RRNA Catabolic Process RRNA Metabolic Process Exosome (RNase Complex) Negative Regulation Of Metabolic Process MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Exonuclease Activity Nucleolus SnRNA Metabolic Process RRNA Processing Macromolecule Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Regulation Of Gene Expression RNA 3'-end Processing Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process RRNA 3'-end Processing 5'-3' Exonuclease Activity TRNA Decay RNA Metabolic Process Regulation Of Telomere Maintenance Nuclease Activity RNA Binding Regulation Of Macromolecule Metabolic Process Sno(s)RNA Metabolic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity Nuclear RNA Surveillance RNA Binding RNA Surveillance U4 SnRNA 3'-end Processing SnRNA Metabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process RNA Processing Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process SnRNA 3'-end Processing MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Processing SnRNA Processing Exoribonuclease Complex Sno(s)RNA Metabolic Process RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Nucleic Acid Metabolic Process RNA 3'-end Processing Nucleoplasm RRNA 3'-end Processing TRNA Decay Nucleobase-containing Compound Metabolic Process Nucleus Macromolecule Metabolic Process Catalytic Step 2 Spliceosome SnRNA Catabolic Process CUT Catabolic Process Macromolecule Catabolic Process Spliceosomal Complex DNA Deamination RNA Splicing Nucleolus Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA
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