CTSH and CSTB

Number of citations of the paper that reports this interaction (PMID 11514663)
2

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CTSH	CSTB
Gene Name		cathepsin H	cystatin B (stefin B)
Image
Gene Ontology Annotations	Cellular Component	Outer Dense Fiber Acrosomal Vesicle Extracellular Space Lysosome Cytosol Extracellular Vesicular Exosome Alveolar Lamellar Body	Extracellular Space Nucleolus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process HLA-A Specific Activating MHC Class I Receptor Activity Kininogen Binding Protein Complex Binding Protein Self-association Thyroid Hormone Binding	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Poly(A) RNA Binding
	Biological Process	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Positive Regulation Of Peptidase Activity Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of Angiogenesis Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Negative Regulation Of Proteolysis
Pathways		MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS		Bipolar disorder ( 21771265) Type 1 diabetes ( 19430480 18978792)
Protein-Protein Interactions		5 interactors: BGLAP CSTA CSTB SFTPB XRN1	8 interactors: CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2
Entrez ID		1512	1476
HPRD ID		00288	03091
Ensembl ID
Uniprot IDs		P09668	P04080 Q76LA1
PDB IDs		1BZN	1STF 2OCT
Enriched GO Terms of Interacting Partners?		Response To Vitamin K Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Nuclear MRNA Surveillance Response To Hydroxyisoflavone RNA Surveillance Histone MRNA Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing RRNA Catabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Response To Gravity Cellular Response To Vitamin D Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Osteoblast Development Response To Vitamin D Regulation Of Proteolysis Regulation Of Bone Resorption Response To Testosterone Cellular Response To Nutrient Regulation Of Bone Remodeling Peptide Cross-linking Negative Regulation Of Catalytic Activity Response To Zinc Ion Bone Mineralization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Cellular Protein Metabolic Process Response To Activity Respiratory Gaseous Exchange	Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Epithelial Tube Branching Involved In Lung Morphogenesis Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Lung Morphogenesis Cell Death Death Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Immune Response-regulating Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Catalytic Activity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Response To Organic Substance Toll-like Receptor Signaling Pathway Neuropeptide Catabolic Process Macrophage Apoptotic Process Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteolysis Regulation Of Collagen Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Activation Of Innate Immune Response Regulation Of Cell Death Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Innate Immune Response Catabolic Process Bradykinin Catabolic Process Regulation Of Blood Vessel Remodeling Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Immune Response Response To Stress Regulation Of Cellular Protein Metabolic Process Myeloid Cell Apoptotic Process
Tagcloud ?		17a 23r arntl atf5 ccl20 ccr6 cd40lg ceacam1 covert cxcr6 faslg furin isg20 ltb map3k4 mcam permissiveness ppargamma pseudotyped ptk2 ptpn13 rorc rosiglitazone serpinb6 th1 th1th17 tnfsf13b tnfsf25 vsv	ataxia cerebella cerebellar cerebellum compatible connected cystatin electrophysiological epm1 gabaa gabaergic granule hyperexcitable implies interneurons lundborg manifesting myoclonus neuroinflammation p30 p7 pathogenetic pinpointed precedes purkinje recessively recordings terminals unverricht
Tagcloud (Difference) ?		17a 23r arntl atf5 ccl20 ccr6 cd40lg ceacam1 covert cxcr6 faslg furin isg20 ltb map3k4 mcam permissiveness ppargamma pseudotyped ptk2 ptpn13 rorc rosiglitazone serpinb6 th1 th1th17 tnfsf13b tnfsf25 vsv	ataxia cerebella cerebellar cerebellum compatible connected cystatin electrophysiological epm1 gabaa gabaergic granule hyperexcitable implies interneurons lundborg manifesting myoclonus neuroinflammation p30 p7 pathogenetic pinpointed precedes purkinje recessively recordings terminals unverricht
Tagcloud (Intersection) ?