CTSH and SFTPB

Number of citations of the paper that reports this interaction (PubMedID 14766755)
0

Data Source:
HPRD (in vitro)

		CTSH	SFTPB
Description		cathepsin H	surfactant protein B
Image
GO Annotations	Cellular Component	Outer Dense Fiber Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytosol Axoneme Extracellular Matrix Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity HLA-A Specific Activating MHC Class I Receptor Activity Kininogen Binding Identical Protein Binding Protein-containing Complex Binding Thyroid Hormone Binding	Protein Binding
	Biological Process	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Apoptotic Process Immune Response Spermatogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Surfactant Homeostasis Proteolysis Involved In Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Lysosomal Protein Catabolic Process Response To Odorant Positive Regulation Of Apoptotic Signaling Pathway	Lipid Metabolic Process Sphingolipid Metabolic Process Respiratory Gaseous Exchange By Respiratory System Animal Organ Morphogenesis
Pathways		MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation	Surfactant metabolism Defective pro-SFTPB causes SMDP1 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs		N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
Diseases		Type I diabetes mellitus	Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Aspartate aminotransferase levels ( 33547301) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 24076602 31604244) Narcolepsy ( 23459209) Type 1 diabetes ( 18978792 19430480 25751624 30572963)	Blood protein levels ( 30072576)
Interacting Genes		5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1	2 interacting genes: CTSH MEOX2
Entrez ID		1512	6439
HPRD ID		00288	01523
Ensembl ID		ENSG00000103811	ENSG00000168878
Uniprot IDs		E9PKT6 P09668	P07988
PDB IDs		6CZK 6CZS	1DFW 1KMR 1RG3 1RG4 1SSZ 2DWF 2JOU 2M0H 2M1T
Enriched GO Terms of Interacting Partners?		Response To Testosterone Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Extracellular Space Peptidase Inhibitor Activity Protease Binding Negative Regulation Of Protein Metabolic Process Cellular Response To Puromycin Cellular Response To Cycloheximide Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Proteolysis Hydroxyapatite Binding Response To Vitamin K Response To Hydroxyisoflavone Response To Gravity Response To Phenylpropanoid Response To Ketone Regulation Of Testosterone Biosynthetic Process Cellular Response To Zinc Ion Starvation Peptidase Inhibitor Complex Multivesicular Body Lumen Lamellar Body Alveolar Lamellar Body Response To Cycloheximide 5'-3' RNA Exonuclease Activity Response To Alcohol G-quadruplex RNA Binding Response To Macrophage Colony-stimulating Factor G-quadruplex DNA Binding Regulation Of Bone Development 5'-3' Exonuclease Activity Cellular Response To Vitamin D Nuclear MRNA Surveillance Histone MRNA Catabolic Process Regulation Of Proteolysis RRNA Catabolic Process Type B Pancreatic Cell Proliferation Peptide Cross-linking Positive Regulation Of Neurotransmitter Secretion Regulation Of Ketone Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Clathrin-coated Endocytic Vesicle Dendrite Histone MRNA Metabolic Process Response To Vitamin D Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Telomere Maintenance Via Telomere Lengthening	Kininogen Binding HLA-A Specific Activating MHC Class I Receptor Activity Bradykinin Catabolic Process Neuropeptide Catabolic Process Alveolar Lamellar Body Outer Dense Fiber Response To Odorant Peptidase Activator Activity Involved In Apoptotic Process Multivesicular Body Lumen Thyroid Hormone Binding Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Somite Specification PAM Complex, Tim23 Associated Import Motor Lysosomal Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Catabolic Process In The Vacuole Segment Specification Somite Development TIM23 Mitochondrial Import Inner Membrane Translocase Complex Adenyl-nucleotide Exchange Factor Activity Peptide Catabolic Process Surfactant Homeostasis T Cell Mediated Cytotoxicity Response To Thyroid Hormone Protein Import Into Mitochondrial Matrix Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Aminopeptidase Activity T Cell Mediated Immunity Membrane Protein Proteolysis Metanephros Development Zymogen Activation Protein Localization To Mitochondrion
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