SMARCC2 and BAZ1B

Number of citations of the paper that reports this interaction (PubMedID 12837248)
0

Data Source:
HPRD (in vivo, in vitro)

		SMARCC2	BAZ1B
Description		SWI/SNF related BAF chromatin remodeling complex subunit C2	bromodomain adjacent to zinc finger domain 1B
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GO Annotations	Cellular Component	Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Chromatin Condensed Chromosome Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus Nuclear Replication Fork WICH Complex B-WICH Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding	Nucleotide Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Histone Kinase Activity Histone Binding Metal Ion Binding Histone H2AXY142 Kinase Activity
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Mitotic Chromosome Condensation
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Asthma ( 31619474) Refractive error ( 32231278)	C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Hip index ( 34021172) Hypertriglyceridemia ( 23505323) Hyperuricemia ( 29124443) Lamb consumption ( 32066663) Lipoprotein (a) levels ( 33730874) Malaria ( 31844061) Meat-related diet ( 32066663) Metabolic syndrome ( 31589552) Migraine ( 27182965) Non-oily fish consumption ( 32066663) Platelet count ( 32888494) Protein C levels ( 20802025) Pursuit maintenance gain ( 29064472) Serum alkaline phosphatase levels ( 33339817) Serum uric acid levels ( 30993211) Triglyceride levels ( 32203549) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818) Triglycerides ( 20864672) Urate levels ( 31985003 23263486) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		27 interacting genes: ARRB2 ATXN1 ATXN1L BAZ1B CEBPA CSNK2A1 EWSR1 FUS GATA1 IFTAP ITCH ITSN1 KLF1 KRT27 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RBPMS RELB SP1 SRGAP3 TAF15 TERF1 USP7	16 interacting genes: CDT1 H2AX KANSL1 KAT8 MAILR MTNR1A MYO1C NR4A2 PCNA RNF10 SIRT1 SMARCA1 SMARCA5 SMARCC2 SMARCE1 SUMO2
Entrez ID		6601	9031
HPRD ID		03437	10416
Ensembl ID		ENSG00000139613	ENSG00000009954
Uniprot IDs		F8VXC8 Q8TAQ2	Q9UIG0
PDB IDs		6KAG 6LTH 6LTJ 7VDV 7Y8R	1F62 5NNF
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process POZ Domain Binding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere DNA-templated Transcription Nucleus Identical Protein Binding MRNA 3'-UTR Binding Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Adaptor Activity Regulation Of Chromosome Condensation Negative Regulation Of RNA Metabolic Process DNA Binding Myeloid Cell Apoptotic Process Macromolecule Biosynthetic Process Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Postsynapse Regulation Of Chromosome Organization Myeloid Cell Differentiation Rhythmic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Chromatin Binding Granulocyte Differentiation Memory Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Heterochromatin Formation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Kinetochore Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Double-strand Break Repair Chromatin Regulation Of DNA Repair Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression CERF Complex Nucleosome Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleosome Array Spacer Activity Regulation Of Double-strand Break Repair Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Histone Binding NURF Complex RDNA Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromosome B-WICH Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process BBAF Complex Regulation Of Mitochondrial Transcription Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex
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