SMARCC2 and MCPH1

Number of citations of the paper that reports this interaction (PMID 19525936)
46

Data Source:
BioGRID (pull down)

		SMARCC2	MCPH1
Gene Name		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	microcephalin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm SWI/SNF Complex Transcriptional Repressor Complex Protein Complex NpBAF Complex NBAF Complex	Nucleoplasm Cytoplasm Microtubule Organizing Center
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Mitotic Cell Cycle Cerebral Cortex Development
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Cytomegalovirus antibody response ( 21993531) Epirubicin-induced leukopenia ( 21799462)
Protein-Protein Interactions		21 interactors: ARRB2 ATXN1 ATXN1L BAZ1B C11orf74 CSNK2A1 GATA1 ITCH ITSN1 KLF1 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RELB SP1 SRGAP3 TERF1 TERF2IP	9 interactors: ABCC2 CHEK1 H2AFX KDM1A MCM2 PHF11 SMARCB1 SMARCC2 TADA2A
Entrez ID		6601	79648
HPRD ID		03437	06174
Ensembl ID		ENSG00000139613	ENSG00000147316
Uniprot IDs		F8VXC8 Q8TAQ2	Q8NEM0
PDB IDs			2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Cellular Process Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Developmental Process Nitrogen Compound Metabolic Process Regulation Of Signaling Myeloid Cell Differentiation Negative Regulation Of Chromosome Organization Regulation Of Organelle Organization Biosynthetic Process Regulation Of Cellular Component Organization Anatomical Structure Development Negative Regulation Of Binding Erythrocyte Differentiation System Development Rhythmic Process Response To Stimulus Erythrocyte Homeostasis Regulation Of Telomere Maintenance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Gene Expression RNA-dependent DNA Replication Megakaryocyte Differentiation Myeloid Cell Homeostasis Organ Development	Chromatin Organization Chromosome Organization Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Modification Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Nucleosome Disassembly Nucleobase-containing Compound Metabolic Process Cell Cycle Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Remodeling Regulation Of Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair ATP-dependent Chromatin Remodeling Histone Modification Biosynthetic Process Regulation Of Primitive Erythrocyte Differentiation DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Prostaglandin Transport Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-T11 Phosphorylation Transcription, DNA-templated Nucleosome Assembly RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Chromatin Assembly DNA Repair Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Protein-DNA Complex Assembly Positive Regulation Of Gene Expression
Tagcloud ?		affymetrix arrays c10orf18 cabp4 capn10 centb1 converted fdr fractioned genechip glycerol hybridized or4c6 papillary ran sall1 serous spata13 splicing st st18 subcellular supernatants supraspliceosome transcriptome wdr78 znf263 zp2 zranb2	8p23 aberrantly advance alleviated aneuploidy bona break breaks brit1 centrosome chromatid comet convincing doi dsb fide heterozygosity joining karyotyping lymphomas meanwhile mefs metaphase multiplication onc online publication reconstituted
Tagcloud (Difference) ?		affymetrix arrays c10orf18 cabp4 capn10 centb1 converted fdr fractioned genechip glycerol hybridized or4c6 papillary ran sall1 serous spata13 splicing st st18 subcellular supernatants supraspliceosome transcriptome wdr78 znf263 zp2 zranb2	8p23 aberrantly advance alleviated aneuploidy bona break breaks brit1 centrosome chromatid comet convincing doi dsb fide heterozygosity joining karyotyping lymphomas meanwhile mefs metaphase multiplication onc online publication reconstituted
Tagcloud (Intersection) ?